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Old 07-25-2011
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Question Myasthenia gravis auto-antibodies and Drugs to avoid

Hi all:

I would like to know that myasthenia gravis(MS) autoantibody only works on neuromuscular junction? namely, Ach nicotinic receptor on striated muscle, how about other receptors? besides, if autoantibody works on nicotinic receptors, how about those sympathetic and parasympathetic ganglions? these gaglions are also Ach nicotinic.

In Goljan, the treatment says that we should avoid certain medications: b-blockers, aminoglycosides, quinolone antibiotics, class I antiarrhythmics.
Can someone please explain why we need to avoid these medications?

Thank you for your answering!
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Old 07-25-2011
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myasthenia is caused due to Ab directed against nicotinic receptors on motor end palate n there re sme autoAb against MuSK protein,a tyrosine kinase protein, involved in formation of nicotinic reptors at NMJ...
n these drugs ve atropine like side effects which aggravte the symptoms of MG
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Old 07-25-2011
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Quote:
Originally Posted by qurat21 View Post
myasthenia is caused due to Ab directed against nicotinic receptors on motor end palate n there re sme autoAb against MuSK protein,a tyrosine kinase protein, involved in formation of nicotinic reptors at NMJ...
n these drugs ve atropine like side effects which aggravte the symptoms of MG
so you mean b-blockers, aminoglycosides they also have atropine-like side effects?

can you please explain especially b-blockers?
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