Drug contraindicated in Gastroparesis and Epilepsy! - USMLE Forums
USMLE Forums Logo
USMLE Forums         Your Reliable USMLE Online Community     Members     Posts
Home
USMLE Articles
USMLE News
USMLE Polls
USMLE Books
USMLE Apps
Go Back   USMLE Forums > USMLE Step 1 Forum

USMLE Step 1 Forum USMLE Step 1 Discussion Forum: Let's talk about anything related to USMLE Step 1 exam


Reply
 
Thread Tools Search this Thread Display Modes
  #1  
Old 07-27-2011
USMLE Forums Addict
 
Steps History: Not yet
Posts: 103
Threads: 46
Thanked 171 Times in 48 Posts
Reputation: 181
Drug Drug contraindicated in Gastroparesis and Epilepsy!

A diabetic with gastroparesis and epilepsy, which of the following drugs are contraindicated
a) Metoclopramide
b) Macrolides
c) Bethanecol
d) Neostigmine
Reply With Quote Quick reply to this message
The above post was thanked by:
Ace3 (07-27-2011), jahn77 (07-27-2011), star123 (07-27-2011)



  #2  
Old 07-27-2011
bebix's Avatar
USMLE Forums Master
 
Steps History: 1+CK+CS+3
Posts: 1,357
Threads: 194
Thanked 3,259 Times in 881 Posts
Reputation: 3269
Default

Metoclopramide is contraindicated in patients with seizures
Reply With Quote Quick reply to this message
  #3  
Old 07-27-2011
USMLE Forums Newbie
 
Steps History: Not yet
Posts: 1
Threads: 0
Thanked 0 Times in 0 Posts
Reputation: 10
Default

Quote:
Originally Posted by saintdizzy View Post
A diabetic with gastroparesis and epilepsy, which of the following drugs are contraindicated
a) Metoclopramide
b) Macrolides
c) Bethanecol
d) Neostigmine
metoclopramide
Reply With Quote Quick reply to this message
  #4  
Old 07-27-2011
akua's Avatar
USMLE Forums Addict
 
Steps History: Not yet
Posts: 167
Threads: 0
Thanked 31 Times in 31 Posts
Reputation: 41
Default

A:metoclopramide
Reply With Quote Quick reply to this message
  #5  
Old 07-27-2011
USMLE Forums Master
 
Steps History: 1+CK+CS+3
Posts: 1,175
Threads: 38
Thanked 852 Times in 478 Posts
Reputation: 862
Default

Quote:
Originally Posted by bebix View Post
Metoclopramide is contraindicated in patients with seizures
Is it just because it works on the CTZ or is there any other reason?
__________________
PGY-3
To view links or images in signatures your post count must be 10 or greater. You currently have 0 posts.
Reply With Quote Quick reply to this message
  #6  
Old 07-27-2011
qurat21's Avatar
USMLE Forums Master
 
Steps History: 1 + CK
Posts: 623
Threads: 62
Thanked 287 Times in 186 Posts
Reputation: 297
Default

[QUOTE=saintdizzy;56496]A diabetic with gastroparesis and epilepsy, which of the following drugs are contraindicated
a) Metoclopramide
b) Macrolides
c) Bethanecol
d) Neostigmine[/QUOTe


of these i believe metoclopramide but one thing i wud like to knw tht in gastroperisis there is vagus n. damage n metoclopramide enhances effect of Ach it improves gut motility so shud it b contraindicated in gastroparesis
neostigmine n bathenecol dnt ve access to brain.
Reply With Quote Quick reply to this message
  #7  
Old 07-27-2011
drnirajmavani's Avatar
USMLE Forums Veteran
 
Steps History: Step 1 Only
Posts: 268
Threads: 14
Thanked 103 Times in 69 Posts
Reputation: 113
Default

A) . metoclopramide as it has seizure inducing potential...dunno the mechanism...ne input would be appreciated
Reply With Quote Quick reply to this message
  #8  
Old 07-27-2011
yasirsattar75's Avatar
USMLE Forums Guru
 
Steps History: Not yet
Posts: 395
Threads: 51
Thanked 292 Times in 111 Posts
Reputation: 302
Default

metoclopramide is partial agonist at Dopamine recptors thats why it causes seizures
Reply With Quote Quick reply to this message
The above post was thanked by:
Ace3 (07-27-2011)
  #9  
Old 07-27-2011
USMLE Forums Veteran
 
Steps History: ---
Posts: 250
Threads: 19
Thanked 43 Times in 39 Posts
Reputation: 53
Default

yea, a definitely.
Reply With Quote Quick reply to this message
  #10  
Old 07-27-2011
USMLE Forums Master
 
Steps History: Step 1 Only
Posts: 566
Threads: 25
Thanked 522 Times in 263 Posts
Reputation: 532
Default

...Interesting Metoclopramide is indicate on Pte with gastroparesis but there are a few drugs that we should know that low or decrease seizure threshold therefore, predispone the patient to SEIZURE.

1. Metoclopramide
2. Theophiline
3. Enfluerane (fixed)
4. Desipramine
5. Bupropion
6. Tramadol

Those are the list i made reading through FA... Feel free to add any other med.


Answer is A... The rest of the list Improve Bowel Movement...

Last edited by rulz; 07-28-2011 at 06:24 AM.
Reply With Quote Quick reply to this message
The above post was thanked by:
bandar (07-27-2011), bebix (07-27-2011), drhnis (07-27-2011), star123 (07-28-2011)
  #11  
Old 07-27-2011
USMLE Forums Master
 
Steps History: Step 1 Only
Posts: 566
Threads: 25
Thanked 522 Times in 263 Posts
Reputation: 532
Default

Quote:
Originally Posted by drnirajmavani View Post
A) . metoclopramide as it has seizure inducing potential...dunno the mechanism...ne input would be appreciated
Its a Dopamine -2 antagonist ( peripherial and central ) and Sensitize Ach Action.
Reply With Quote Quick reply to this message
The above post was thanked by:
drnirajmavani (08-05-2011)
  #12  
Old 07-27-2011
USMLE Forums Scout
 
Steps History: 1+CK+CS
Posts: 36
Threads: 3
Thanked 21 Times in 14 Posts
Reputation: 31
Default

Quote:
Originally Posted by rulz View Post
...Interesting Metoclopramide is indicate on Pte with gastroparesis but there are a few drugs that we should know that low or decrease seizure threshold therefore, predispone the patient to SEIZURE.

1. Metoclopramide
2. Theophiline
3. Influerane
4. Desipramine
5. Bupropion
6. Tramadol

Those are the list i made reading through FA... Feel free to add any other med.


Answer is A... The rest of the list Improve Bowel Movement...
In first aid, 2010 edi pg no 241-
he has mentioned some seizure causing drugs-
-Imipenem/Cisplastin
-Isoniazid ( if given without Pyridoxine supplementation)
Reply With Quote Quick reply to this message
  #13  
Old 07-27-2011
bebix's Avatar
USMLE Forums Master
 
Steps History: 1+CK+CS+3
Posts: 1,357
Threads: 194
Thanked 3,259 Times in 881 Posts
Reputation: 3269
Default

Quote:
Originally Posted by rulz View Post
...Interesting Metoclopramide is indicate on Pte with gastroparesis but there are a few drugs that we should know that low or decrease seizure threshold therefore, predispone the patient to SEIZURE.

1. Metoclopramide
2. Theophiline
3. Influerane
4. Desipramine
5. Bupropion
6. Tramadol

Those are the list i made reading through FA... Feel free to add any other med.

Thanks!!!...(#3 Enflurane)
Reply With Quote Quick reply to this message
The above post was thanked by:
akua (07-27-2011), rulz (07-28-2011)
  #14  
Old 07-28-2011
USMLE Forums Addict
 
Steps History: Not yet
Posts: 151
Threads: 39
Thanked 52 Times in 29 Posts
Reputation: 62
Warning! A

a) Metoclopramide
Reply With Quote Quick reply to this message
  #15  
Old 07-28-2011
USMLE Forums Master
 
Steps History: Step 1 Only
Posts: 566
Threads: 25
Thanked 522 Times in 263 Posts
Reputation: 532
Default

Quote:
Originally Posted by bebix View Post
Thanks!!!...(#3 Enflurane)
Thanks to you! =) hehe, Let me fix it :P
Reply With Quote Quick reply to this message



  #16  
Old 07-31-2011
USMLE Forums Scout
 
Steps History: Not yet
Posts: 70
Threads: 5
Thanked 13 Times in 10 Posts
Reputation: 23
Default

Quote:
Originally Posted by saintdizzy View Post
A diabetic with gastroparesis and epilepsy, which of the following drugs are contraindicated
a) Metoclopramide
b) Macrolides
c) Bethanecol
d) Neostigmine

Metoclopramide.
Reply With Quote Quick reply to this message



Reply

Tags
Pharmacology-, Step-1-Questions

Quick Reply
Message:
Options

Register Now

In order to be able to post messages on the USMLE Forums forums, you must first register.
Please enter your desired user name, your email address and other required details in the form below.
User Name:
Password
Please enter a password for your user account. Note that passwords are case-sensitive.
Password:
Confirm Password:
Email Address
Please enter a valid email address for yourself.
Email Address:
Medical School
Choose "---" if you don't want to tell. AMG for US & Canadian medical schools. IMG for all other medical schools.
USMLE Steps History
What steps finished! Example: 1+CK+CS+3 = Passed Step 1, Step 2 CK, Step 2 CS, and Step 3.

Choose "---" if you don't want to tell.

Favorite USMLE Books
What USMLE books you really think are useful. Leave blank if you don't want to tell.
Location
Where you live. Leave blank if you don't want to tell.

Log-in

Human Verification

In order to verify that you are a human and not a spam bot, please enter the answer into the following box below based on the instructions contained in the graphic.



Thread Tools Search this Thread
Search this Thread:

Advanced Search
Display Modes


Similar Threads
Thread Thread Starter Forum Replies Last Post
barbiturates contraindicated in porphyria patients yasirsattar75 USMLE Step 1 Forum 1 07-14-2011 06:02 PM
'HAM' is Contraindicated for Succinylcholine! anila USMLE Step 1 Mnemonics 0 12-08-2010 10:56 AM
Which NSAID is contraindicated in Gout mtoi USMLE Step 1 Forum 2 11-21-2010 05:04 PM
Epilepsy Drug Target Yallah USMLE Step 1 Forum 4 07-07-2010 02:20 PM
Drug of Choice for Epilepsy During Pregnancy? obgynaim USMLE Step 2 CK Forum 2 03-22-2010 08:10 PM

RSS Feed
Find Us on Facebook
vBulletin Security provided by vBSecurity v2.2.2 (Pro) - vBulletin Mods & Addons Copyright © 2017 DragonByte Technologies Ltd.

USMLE® & other trade marks belong to their respective owners, read full disclaimer
USMLE Forums created under Creative Commons 3.0 License. (2009-2014)