Tumor marker question - USMLE Forums
USMLE Forums Logo
USMLE Forums         Your Reliable USMLE Online Community     Members     Posts
Home
USMLE Articles
USMLE News
USMLE Polls
USMLE Books
USMLE Apps
Go Back   USMLE Forums > USMLE Step 1 Forum

USMLE Step 1 Forum USMLE Step 1 Discussion Forum: Let's talk about anything related to USMLE Step 1 exam


Reply
 
Thread Tools Search this Thread Display Modes
  #1  
Old 07-27-2011
mle2resident's Avatar
USMLE Forums Veteran
 
Steps History: 1 + CS
Posts: 252
Threads: 51
Thanked 185 Times in 94 Posts
Reputation: 195
Star Tumor marker question

Microscopic pic of a 45 year old man's brain tumor shows glial neoplasm with atypical astrocytes, scattered mitosis. In addition to the mitotic activity, which tumor marker provides information of its proliferative action.

A. bcl-2
B. GFAP
C. Ki-67
D. p53
E. Ubiquitin
Reply With Quote Quick reply to this message
The above post was thanked by:
dr_lizard (07-28-2011), dr.digant (07-28-2011), jahn77 (07-27-2011), pass7 (07-28-2011), riya10 (07-28-2011), struggle (07-28-2011), usmle2011 (07-27-2011)



  #2  
Old 07-27-2011
jahn77's Avatar
USMLE Forums Guru
 
Steps History: Step 1 Only
Posts: 326
Threads: 20
Thanked 220 Times in 124 Posts
Reputation: 232
Default

c) Ki-67 is proliferation marker
Reply With Quote Quick reply to this message
The above post was thanked by:
usmle2011 (07-27-2011)
  #3  
Old 07-27-2011
jaimin's Avatar
USMLE Forums Veteran
 
Steps History: 1+CK+CS+3
Posts: 264
Threads: 15
Thanked 98 Times in 56 Posts
Reputation: 108
Default

B- GFAP - Neurogilal Marker,Not sure if it is tumor marker.
Reply With Quote Quick reply to this message
  #4  
Old 07-27-2011
yasirsattar75's Avatar
USMLE Forums Guru
 
Steps History: Not yet
Posts: 395
Threads: 51
Thanked 292 Times in 111 Posts
Reputation: 302
Default

B sure , glial fibrillary acid protein . GFAP
Reply With Quote Quick reply to this message
  #5  
Old 07-28-2011
qurat21's Avatar
USMLE Forums Master
 
Steps History: 1 + CK
Posts: 623
Threads: 62
Thanked 287 Times in 186 Posts
Reputation: 297
Default

Quote:
Originally Posted by mle2resident View Post
Microscopic pic of a 45 year old man's brain tumor shows glial neoplasm with atypical astrocytes, scattered mitosis. In addition to the mitotic activity, which tumor marker provides information of its proliferative action.

A. bcl-2
B. GFAP
C. Ki-67
D. p53
E. Ubiquitin
GFAP is the marker for astrocytes
Reply With Quote Quick reply to this message
  #6  
Old 07-28-2011
dr.digant's Avatar
USMLE Forums Addict
 
Steps History: Step 1 Only
Posts: 127
Threads: 21
Thanked 103 Times in 53 Posts
Reputation: 113
Default

Quote:
Originally Posted by mle2resident View Post
Microscopic pic of a 45 year old man's brain tumor shows glial neoplasm with atypical astrocytes, scattered mitosis. In addition to the mitotic activity, which tumor marker provides information of its proliferative action.

A. bcl-2
B. GFAP
C. Ki-67
D. p53
E. Ubiquitin
question is about proliferaation ....so answer is ki-67...its marker of proliferation...GFAP is not proliferation marker its astrocyte marker...
Reply With Quote Quick reply to this message
  #7  
Old 07-28-2011
USMLE Forums Guru
 
Steps History: Not yet
Posts: 417
Threads: 74
Thanked 129 Times in 93 Posts
Reputation: 139
Default

Quote:
Originally Posted by mle2resident View Post
Microscopic pic of a 45 year old man's brain tumor shows glial neoplasm with atypical astrocytes, scattered mitosis. In addition to the mitotic activity, which tumor marker provides information of its proliferative action.

A. bcl-2
B. GFAP
C. Ki-67
D. p53
E. Ubiquitin
bbbbbbbbbbbbbb
Reply With Quote Quick reply to this message
  #8  
Old 07-28-2011
USMLE Forums Addict
 
Steps History: Not yet
Posts: 151
Threads: 39
Thanked 52 Times in 29 Posts
Reputation: 62
Star B

B. GFAP

Astrocytoma.
Reply With Quote Quick reply to this message
  #9  
Old 07-28-2011
USMLE Forums Master
 
Steps History: Step 1 Only
Posts: 566
Threads: 25
Thanked 522 Times in 263 Posts
Reputation: 532
Default

Yeap, he is right regarding the Ki-67. The GFAP helps to identify for The astrocytoma but don't assets what is asking in the question.

Answer is C
Reply With Quote Quick reply to this message
The above post was thanked by:
docusmle9 (07-28-2011)
  #10  
Old 07-28-2011
Hope2Pass's Avatar
USMLE Forums Master
 
Steps History: 1+CK+CS+3
Posts: 1,684
Threads: 213
Thanked 1,590 Times in 660 Posts
Reputation: 1600
Correct Answer

Hey guys,

I didn't know the answer to this so I looked it up on google and found the exact same question answered on a different forum. I wasn't sure what Ki-67 was!


Quote:
The correct answer is C. Ki-67 is a nuclear factor (of uncertain function) whose expression correlates with neoplastic replicative activity. Its expression can be visualized by immunostaining of formalin-fixed, paraffin-embedded sections. Ki-67 labeling correlates with a neoplasm's rate of growth and, therefore, with prognosis.

The bcl-2 gene (choice A) suppresses apoptosis by different mechanisms. Its abnormal activation is involved in the pathogenesis of low-grade lymphomas but not astrocytomas.

GFAP (choice B) is an intermediate cytoskeletal filament (analogue of keratin and vimentin) expressed exclusively by certain types of glial cells, e.g., astrocytes and ependymal cells. Immunohistochemistry for GFAP is used diagnostically to confirm an astrocytic origin of a neoplasm, but gives no information about mitotic or proliferative rate.

The gene p53 (choice D) encodes a protein that blocks the cell cycle when damage to DNA occurs. If the damage is successfully repaired, p53 allows the cell cycle to resume; if not, p53 induces apoptosis, thus eliminating dangerous DNA mutations. Mutations of p53 have been found in the great majority of human neoplasms, including gliomas. However, its expression gives no information concerning neoplastic replicative activity.

Ubiquitin (choice E) is a low-molecular-weight heat-shock protein. Its function is to tag aberrant proteins for degradation. It is present in many abnormal intraneuronal inclusions associated with neurodegenerative disorders, such as Lewy bodies, Pick bodies, and neurofibrillary tangles. It has no relationship with mitotic activity or growth rate.
Source: http://www.prep4usmle.com/forum/thread/34762/
Reply With Quote Quick reply to this message
The above post was thanked by:
bandar (07-28-2011), bebix (07-28-2011), docusmle9 (07-28-2011), lucas05 (07-28-2011), mle2resident (07-28-2011), riya10 (07-28-2011), rulz (07-28-2011), struggle (07-28-2011), usmle2011 (07-28-2011)
  #11  
Old 07-28-2011
USMLE Forums Scout
 
Steps History: ---
Posts: 31
Threads: 3
Thanked 6 Times in 6 Posts
Reputation: 16
Default

B is the answer.GFAP
Reply With Quote Quick reply to this message
  #12  
Old 07-28-2011
USMLE Forums Veteran
 
Steps History: ---
Posts: 250
Threads: 19
Thanked 43 Times in 39 Posts
Reputation: 53
Default

i'll go for ki-67
Reply With Quote Quick reply to this message
  #13  
Old 07-28-2011
riya10's Avatar
USMLE Forums Addict
 
Steps History: Not yet
Posts: 124
Threads: 13
Thanked 59 Times in 43 Posts
Reputation: 69
Correct Answer

Quote:
Originally Posted by Hope2Pass View Post
Hey guys,

I didn't know the answer to this so I looked it up on google and found the exact same question answered on a different forum. I wasn't sure what Ki-67 was!




Source: http://www.prep4usmle.com/forum/thread/34762/
yup!!!!you r right.....
Reply With Quote Quick reply to this message
The above post was thanked by:
Hope2Pass (07-28-2011)
  #14  
Old 07-28-2011
mle2resident's Avatar
USMLE Forums Veteran
 
Steps History: 1 + CS
Posts: 252
Threads: 51
Thanked 185 Times in 94 Posts
Reputation: 195
Arrow Correct Answer is C. Ki-67.

The right answer is Ki-67.
Thanks to Hope2Pass, u saved me some writing here.
The question is from Kaplan q-bank and only 20% got this question right.
Reply With Quote Quick reply to this message
The above post was thanked by:
Hope2Pass (07-28-2011), usluipek (07-28-2011), usmle2011 (07-28-2011)



Reply

Quick Reply
Message:
Options

Register Now

In order to be able to post messages on the USMLE Forums forums, you must first register.
Please enter your desired user name, your email address and other required details in the form below.
User Name:
Password
Please enter a password for your user account. Note that passwords are case-sensitive.
Password:
Confirm Password:
Email Address
Please enter a valid email address for yourself.
Email Address:
Medical School
Choose "---" if you don't want to tell. AMG for US & Canadian medical schools. IMG for all other medical schools.
USMLE Steps History
What steps finished! Example: 1+CK+CS+3 = Passed Step 1, Step 2 CK, Step 2 CS, and Step 3.

Choose "---" if you don't want to tell.

Favorite USMLE Books
What USMLE books you really think are useful. Leave blank if you don't want to tell.
Location
Where you live. Leave blank if you don't want to tell.

Log-in

Human Verification

In order to verify that you are a human and not a spam bot, please enter the answer into the following box below based on the instructions contained in the graphic.



Thread Tools Search this Thread
Search this Thread:

Advanced Search
Display Modes


Similar Threads
Thread Thread Starter Forum Replies Last Post
The marker findings in Down syndrome bebix USMLE Step 2 CK Forum 3 05-28-2011 11:36 AM
Use of White board and marker durng exam evavar USMLE Step 1 Forum 3 04-05-2011 10:34 AM
Marker Board!...is it cheating? noone_123i USMLE Step 1 Forum 2 03-06-2011 01:14 PM
Marker Board! noone_123i USMLE Step 1 Forum 3 01-22-2011 06:05 AM
CEA Cancer Marker jackat1000 USMLE Step 1 Mnemonics 0 02-18-2010 09:38 AM

RSS Feed
Find Us on Facebook
vBulletin Security provided by vBSecurity v2.2.2 (Pro) - vBulletin Mods & Addons Copyright © 2017 DragonByte Technologies Ltd.

USMLE® & other trade marks belong to their respective owners, read full disclaimer
USMLE Forums created under Creative Commons 3.0 License. (2009-2014)