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Old 07-30-2011
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Default can someone explain plz :Pharm

How does Ticlopidine causes thrombocytopenia?,i came across in goljan that ticlopidine and clopidogrel causes endothelial injury,if so isnt that a predisposition to clot formation?


REf: pg 257,3rd edition Goljan..under Thrombotic thrombocytopenic purpura..


thanks in advance for the reply..
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Old 07-30-2011
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Originally Posted by drgsarunprasath View Post
How does Ticlopidine causes thrombocytopenia?,i came across in goljan that ticlopidine and clopidogrel causes endothelial injury,if so isnt that a predisposition to clot formation?


REf: pg 257,3rd edition Goljan..under Thrombotic thrombocytopenic purpura..


thanks in advance for the reply..
Goljan on his lectures says that in TTP/HUS something in the plasma damages the small vessels throughout your body, so platelets stick, platelets aggregate, and eventually they form firm platelet plugs in all the small vessels in your entire body and if there is this much sticking going on, we CONSUME all the platelets, and this leads to thrombocytopenia, and we can surely bleed.

Of note, if these little platelet thrombi that are strong are distributed in small vessels the RBCs get smashed into it (schistocytes) and we will also have microangiopathic hemolytic anemia.

In conclusion, in TTP/HUS we see low platelet count, prolonged bleeding time, but PT and PTT are normal because coagulation factors are not the ones getting consumed; platelets are.

Hope this helps. Sorry for the extra inputs.
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Old 07-30-2011
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Originally Posted by tootsie View Post
Goljan on his lectures says that in TTP/HUS something in the plasma damages the small vessels throughout your body, so platelets stick, platelets aggregate, and eventually they form firm platelet plugs in all the small vessels in your entire body and if there is this much sticking going on, we CONSUME all the platelets, and this leads to thrombocytopenia, and we can surely bleed.

Of note, if these little platelet thrombi that are strong are distributed in small vessels the RBCs get smashed into it (schistocytes) and we will also have microangiopathic hemolytic anemia.

In conclusion, in TTP/HUS we see low platelet count, prolonged bleeding time, but PT and PTT are normal because coagulation factors are not the ones getting consumed; platelets are.

Hope this helps. Sorry for the extra inputs.




Thanks that was a good explanation,if my question was how does decrease in Platelet occurs in TTP/HUS &Sorry u didnt get my question it was about Ticlopidine,why/How does it causes endothelial injury and thrombocytopenia.
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