Originally Posted by samba
why angiotensin converting enzyme inhibitors reduce the occurance of diabetic nephropathy in DM???
Interesting, in DM we got Glomerular thickening of the Efferent
arteriole, so we got increase of GFR. That's what normally do the AGII but here is overdoing it, making the Glomerular filtration functioning more and obstructing the lumen, increasing the blood pressure, messangial expansion, and as you can see is bad.
When we give the pte ACE inhibitors you are blocking the action of the AGII, because you are giving the patient ACE to block coversion of AG 1 to AG 2.
So, no more Constricting the Efferent Arteriole by AG2. Another concept is that because you are doing this, you are increasing the perfusion to the kidney, in the same say you are decreasing GFR but relative increasing RBF.
This concept is better understand after you know Kidney physiology. Is not the best fancy way to explain it, but is the concept.