Why ACE inhibitors good for DM nephropathy! - USMLE Forums
USMLE Forums Logo
USMLE Forums         Your Reliable USMLE Online Community     Members     Posts
Home
USMLE Articles
USMLE News
USMLE Polls
USMLE Books
USMLE Apps
Go Back   USMLE Forums > USMLE Step 1 Forum

USMLE Step 1 Forum USMLE Step 1 Discussion Forum: Let's talk about anything related to USMLE Step 1 exam


Reply
 
Thread Tools Search this Thread Display Modes
  #1  
Old 08-01-2011
samba's Avatar
USMLE Forums Scout
 
Steps History: Not yet
Posts: 31
Threads: 3
Thanked 8 Times in 8 Posts
Reputation: 18
Drug Why ACE inhibitors good for DM nephropathy!

why angiotensin converting enzyme inhibitors reduce the occurance of diabetic nephropathy in DM???
Reply With Quote Quick reply to this message



  #2  
Old 08-01-2011
USMLE Forums Master
 
Steps History: Step 1 Only
Posts: 566
Threads: 25
Thanked 522 Times in 263 Posts
Reputation: 532
Default

Quote:
Originally Posted by samba View Post
why angiotensin converting enzyme inhibitors reduce the occurance of diabetic nephropathy in DM???
Interesting, in DM we got Glomerular thickening of the Efferent arteriole, so we got increase of GFR. That's what normally do the AGII but here is overdoing it, making the Glomerular filtration functioning more and obstructing the lumen, increasing the blood pressure, messangial expansion, and as you can see is bad.

When we give the pte ACE inhibitors you are blocking the action of the AGII, because you are giving the patient ACE to block coversion of AG 1 to AG 2.

So, no more Constricting the Efferent Arteriole by AG2. Another concept is that because you are doing this, you are increasing the perfusion to the kidney, in the same say you are decreasing GFR but relative increasing RBF.

This concept is better understand after you know Kidney physiology. Is not the best fancy way to explain it, but is the concept.
Reply With Quote Quick reply to this message
The above post was thanked by:
excellence (12-13-2013), samba (08-03-2011)
  #3  
Old 08-03-2011
samba's Avatar
USMLE Forums Scout
 
Steps History: Not yet
Posts: 31
Threads: 3
Thanked 8 Times in 8 Posts
Reputation: 18
Default

Quote:
Originally Posted by rulz View Post
Interesting, in DM we got Glomerular thickening of the Efferent arteriole, so we got increase of GFR. That's what normally do the AGII but here is overdoing it, making the Glomerular filtration functioning more and obstructing the lumen, increasing the blood pressure, messangial expansion, and as you can see is bad.

When we give the pte ACE inhibitors you are blocking the action of the AGII, because you are giving the patient ACE to block coversion of AG 1 to AG 2.

So, no more Constricting the Efferent Arteriole by AG2. Another concept is that because you are doing this, you are increasing the perfusion to the kidney, in the same say you are decreasing GFR but relative increasing RBF.

This concept is better understand after you know Kidney physiology. Is not the best fancy way to explain it, but is the concept.
thanks 4 ur reply !! i studied a line in brs phsiology !! i just wanted to know the concept nd u well described it !! thanx rulzz
Reply With Quote Quick reply to this message
  #4  
Old 08-03-2011
USMLE Forums Master
 
Steps History: Step 1 Only
Posts: 566
Threads: 25
Thanked 522 Times in 263 Posts
Reputation: 532
Default

Always a pleasure. =) Good Luck with your preparation...
Reply With Quote Quick reply to this message
The above post was thanked by:
samba (08-04-2011)



Reply

Tags
Pathology-, Pharmacology-

Quick Reply
Message:
Options

Register Now

In order to be able to post messages on the USMLE Forums forums, you must first register.
Please enter your desired user name, your email address and other required details in the form below.
User Name:
Password
Please enter a password for your user account. Note that passwords are case-sensitive.
Password:
Confirm Password:
Email Address
Please enter a valid email address for yourself.
Email Address:
Medical School
Choose "---" if you don't want to tell. AMG for US & Canadian medical schools. IMG for all other medical schools.
USMLE Steps History
What steps finished! Example: 1+CK+CS+3 = Passed Step 1, Step 2 CK, Step 2 CS, and Step 3.

Choose "---" if you don't want to tell.

Favorite USMLE Books
What USMLE books you really think are useful. Leave blank if you don't want to tell.
Location
Where you live. Leave blank if you don't want to tell.

Log-in

Human Verification

In order to verify that you are a human and not a spam bot, please enter the answer into the following box below based on the instructions contained in the graphic.



Thread Tools Search this Thread
Search this Thread:

Advanced Search
Display Modes


Similar Threads
Thread Thread Starter Forum Replies Last Post
What is the cause of this nephropathy? Chessmatic USMLE Step 2 CK Forum 5 05-11-2012 05:03 PM
A good article on how to put together a good study plan justfree USMLE Links & Free Ads 0 06-13-2011 09:29 AM
Hyaline vs atheromatous lesions / Membranous & Focal Segmental nephropathy Haisook USMLE Step 1 Forum 1 09-18-2010 09:07 AM
Henoch-Schonlein Purpura vs. IgA nephropathy ashishkabir USMLE Step 1 Forum 4 09-14-2010 03:05 AM
Cell Wall Inhibitors anoop_1198 USMLE Step 1 Forum 1 07-28-2010 08:30 PM

RSS Feed
Find Us on Facebook
vBulletin Security provided by vBSecurity v2.2.2 (Pro) - vBulletin Mods & Addons Copyright © 2017 DragonByte Technologies Ltd.

USMLE® & other trade marks belong to their respective owners, read full disclaimer
USMLE Forums created under Creative Commons 3.0 License. (2009-2014)