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  #1  
Old 08-02-2011
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Default hypertriglycedemia

50 yr old man presents to the clinic fr routine evaluation his lipid profile shows
total cholestrol 170mg/dl
triglyceride level 500mg/dl
LDL 100mg/dl
the doctor decides to prescribe

a.lovastatin
b.niacin
c.gemfibrozil
d.cholestyramine
e.no drug only low fat diet
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  #2  
Old 08-02-2011
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c.gemfibrozil
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Old 08-02-2011
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i'll go with C
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Old 08-02-2011
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gemfibrozil....this belongs to fibrates acts by inhibiting lipoprotein lipase...by activating PPAR alpha
these decrease TG and increase HDL
DOC in hypertriglyceridemia type 3 and type 4
feofibrate has longest action
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Old 08-02-2011
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Quote:
Originally Posted by qurat21 View Post
50 yr old man presents to the clinic fr routine evaluation his lipid profile shows
total cholestrol 170mg/dl
triglyceride level 500mg/dl
LDL 100mg/dl
the doctor decides to prescribe

a.lovastatin
b.niacin
c.gemfibrozil
d.cholestyramine
e.no drug only low fat diet
the ans is gemfibrozil it interacts with PPAR alpha
PPARs re peroxisome proliferator activated receptors these re involved in regulation of lipid metabolism these re activated by fatty acids, prostaglandin derivatives,fibrates n thiozolidinediones using zinc fingers
there is going to b improvement in insulin resistance,decrease triglyceride levels.
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