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Old 08-02-2011
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Warning! Cystic fibrosis!

Can a patient with Cystic fibrosis develop Diabetes Mellitus?
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Old 08-02-2011
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Yes it can, as a matter of fact Cystic Fibrosis related Diabetes is one of the most common non-pulmonary manifestations of CF.

The diabetes is secondary to damage to the pancreas caused by thick secretions plugging the ducts of the pancreas.

Furthermore, this pathology also causes malabsorption.

Hope this helps.

Here is a question for you, which is the most common organism that causes pneumonia in patients with Cystic Fibrosis?
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Old 08-02-2011
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Quote:
Originally Posted by USMLE2011m View Post
Yes it can, as a matter of fact Cystic Fibrosis related Diabetes is one of the most common non-pulmonary manifestations of CF.

The diabetes is secondary to damage to the pancreas caused by thick secretions plugging the ducts of the pancreas.

Furthermore, this pathology also causes malabsorption.

Hope this helps.

Here is a question for you, which is the most common organism that causes pneumonia in patients with Cystic Fibrosis?
I think it is staph aureus in early stages late it is pseudomonas
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Quote:
Originally Posted by USMLE2011m View Post
Yes it can, as a matter of fact Cystic Fibrosis related Diabetes is one of the most common non-pulmonary manifestations of CF.

The diabetes is secondary to damage to the pancreas caused by thick secretions plugging the ducts of the pancreas.

Furthermore, this pathology also causes malabsorption.

Hope this helps.

Here is a question for you, which is the most common organism that causes pneumonia in patients with Cystic Fibrosis?
Organisms causing pneumonia in CF;
1. Psuedomonas aeruginosa
2. Staph. aureus
3. H. influenza

But! Diabetes Mellitus is an insufficiency of endocrine pancreas. Endocrine glands by definition secrete their secretions directly into the blood not into the duct of pancreas. Thats where I am confused
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If I understand correctly, then the plugging results in retrograde damage of the pancreas - leading to damage, hence scarring and fibrosis of the pancreas - hence insufficiency. Furthermore, CF also mediates Diabetes via causing chronic pancreatitis.

and yes the organisms are as you mentioned them to be
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Quote:
Originally Posted by usmleman2020 View Post
I think it is staph aureus in early stages late it is pseudomonas
YES you are right !
As quoted by Goljan:

Most common cause of nosocomial pneumonia and death due to pneumonia in cystic fibrosis --> pseudomonas


Major lung palhogen in cystic fibrosis --> Staph aureus

Pseudomonas aerginosa
is the most common respiratory pathogen.
• Other common pathogens—Staph Aureus and H.Influenza
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