Inhibin Question? - USMLE Forums
USMLE Forums Logo
USMLE Forums         Your Reliable USMLE Online Community     Members     Posts
Home
USMLE Articles
USMLE News
USMLE Polls
USMLE Books
USMLE Apps
Go Back   USMLE Forums > USMLE Step 1 Forum

USMLE Step 1 Forum USMLE Step 1 Discussion Forum: Let's talk about anything related to USMLE Step 1 exam


Reply
 
Thread Tools Search this Thread Display Modes
  #1  
Old 01-17-2010
Ex-USMLE Forums Staff
 
Steps History: 1+CK+CS+3
Posts: 753
Threads: 106
Thanked 2,166 Times in 464 Posts
Reputation: 2214
Question Inhibin Question?

If drug X was found to act like inhibin and drug Y was found to be drug X antagonist. Then administering drug Y could result in which of the following?
A- Male infertility
B- Increased Leydig cell testosterone synthesis
C- Decreased secretion of inhibin from granulosa cells
D- Increased FSH secretion from the anterior pituitary
E- Increased GnRH secretion from the hypothalamus
Reply With Quote Quick reply to this message
The above post was thanked by:
Laurentiu (01-19-2010), smile135 (01-21-2010), wahaha007 (01-19-2010)



  #2  
Old 01-17-2010
USMLE Forums Scout
 
Steps History: 1+CK+CS+3
Posts: 54
Threads: 51
Thanked 348 Times in 49 Posts
Reputation: 368
Default

Sertoli cell inhibin produces negative feedback for FSH by the anterior pituitary gonadotrophs...so without Inhibin, FSH secretion production goes wild. Answer is D
Reply With Quote Quick reply to this message
The above post was thanked by:
wahaha007 (01-19-2010)
  #3  
Old 01-17-2010
USMLE Forums Scout
 
Steps History: 1 + CK
Posts: 28
Threads: 0
Thanked 16 Times in 9 Posts
Reputation: 26
Default

antagonistic action of drug Y on drug x -------making normal action of drug x ( ie negative feedback inhibition on FSH secretion ) lost ......leading to increased FSH secretion from the ant pituitary

I choose D ?
Reply With Quote Quick reply to this message
The above post was thanked by:
mayankkaushal (02-01-2014)
  #4  
Old 01-18-2010
ahassan's Avatar
USMLE Forums Scout
 
Steps History: CS Only
Posts: 48
Threads: 0
Thanked 47 Times in 18 Posts
Reputation: 67
Default

D i think is the correct answer
Reply With Quote Quick reply to this message
  #5  
Old 01-18-2010
HouseWannabe's Avatar
USMLE Forums Addict
 
Steps History: 1 + CS
Posts: 120
Threads: 13
Thanked 146 Times in 45 Posts
Reputation: 156
Default

I completely agree with everyone that the answer is D be cause of the loss of the negative feedback on FSH, but i can't help but wonder if there is a loss of that negative feedback, wouldn't it be like having a sertoli cell tumor? Then we would see male infertility???
Reply With Quote Quick reply to this message
  #6  
Old 01-18-2010
Ex-USMLE Forums Staff
 
Steps History: 1+CK+CS+3
Posts: 753
Threads: 106
Thanked 2,166 Times in 464 Posts
Reputation: 2214
Default Correct answer

Yes, the correct answer is D.
Inhibin has so far been of diagnostic significance in male infertility and it's anatagonist theoritcally may cause infertility but there's no such drug yet and it's not proven so you go with the more logical answer which is D.
Reply With Quote Quick reply to this message



Reply

Tags
Endocrine-, Pharmacology-, Step-1-Questions

Quick Reply
Message:
Options

Register Now

In order to be able to post messages on the USMLE Forums forums, you must first register.
Please enter your desired user name, your email address and other required details in the form below.
User Name:
Password
Please enter a password for your user account. Note that passwords are case-sensitive.
Password:
Confirm Password:
Email Address
Please enter a valid email address for yourself.
Email Address:
Medical School
Choose "---" if you don't want to tell. AMG for US & Canadian medical schools. IMG for all other medical schools.
USMLE Steps History
What steps finished! Example: 1+CK+CS+3 = Passed Step 1, Step 2 CK, Step 2 CS, and Step 3.

Choose "---" if you don't want to tell.

Favorite USMLE Books
What USMLE books you really think are useful. Leave blank if you don't want to tell.
Location
Where you live. Leave blank if you don't want to tell.

Log-in

Human Verification

In order to verify that you are a human and not a spam bot, please enter the answer into the following box below based on the instructions contained in the graphic.



Thread Tools Search this Thread
Search this Thread:

Advanced Search
Display Modes


Similar Threads
Thread Thread Starter Forum Replies Last Post
question help: diabetic foot related question dezirablize USMLE Step 2 CK Forum 5 01-15-2015 03:42 PM

RSS Feed
Find Us on Facebook
vBulletin Security provided by vBSecurity v2.2.2 (Pro) - vBulletin Mods & Addons Copyright © 2017 DragonByte Technologies Ltd.

USMLE® & other trade marks belong to their respective owners, read full disclaimer
USMLE Forums created under Creative Commons 3.0 License. (2009-2014)