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  #1  
Old 08-04-2011
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Question Classify this Hyperlipidemia

A patient with familial hypercholesterolemia undergoes a detailed serum lipid and lipoprotein analysis. Studies demonstrate elevated cholesterol in the form of increased LDL without elevation of other lipids. This patient's hyperlipidemia is best classified as which of the following types?

a) Type 1
b) Type 2a
c) Type 2b
d) Type 3
e) Type 5
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  #2  
Old 08-04-2011
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type 2b...LDL receptor gene defect
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Old 08-04-2011
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Quote:
Originally Posted by dr.digant View Post
type 2b...LDL receptor gene defect
I think is type 2a , cause its only LDL
2b i think includes both (familial combined hyperchl)
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i'll go with type 2b
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Old 08-04-2011
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Info the answer is....

The correct answer is B

Explanation
Hyperlipidemia has been subclassified based on the lipid and lipoprotein profiles. Type 2a, which this patient has, can be seen in a hereditary form, known as familial hypercholesterolemia, and also in secondary, acquired forms related to nephritic syndrome and hyperthyroidism. The root problem appears to be a deficiency of LDL receptors, which leads to a specific elevation of cholesterol in the form of increased LDL. Heterozygotes for the hereditary form generally develop cardiovascular disease from 30 to 50 years of age. Homozygotes may have cardiovascular disease in childhood. Type 1 (choice A) is characterized by isolated elevation of chylomicrons. Type 2b (choice C) is characterized by elevations of both cholesterol and triglycerides in the form of LDL and VLDL. Type 3 (choice D) is characterized by elevations of triglycerides and cholesterol in the form of chylomicron remnants and IDL. Type 5 (choice E) is characterized by elevations of triglycerides and cholesterol in the form of VLDL and chylomicrons.
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