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Old 08-05-2011
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Default effect of prednisone

A patient presents with a blood pressure of 160/78 following a liver transplantation. He's been taking prednisone since the transplantation to prevent rejection of his new liver, but now he is hypertensive. What is the cause of his hypertension?

A. Prednisone-induced upregulation of α1-receptors on arterioles

B. One of the general effects of immunosuppresion is hypertension

C. Prednisone-induced increase in cardiac output caused by stimulation of β1-receptors on cardiac muscle

D. ↑ plasma Ca+ levels caused by prednisone

E. None of the above
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Old 08-05-2011
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Originally Posted by ricko335 View Post
A patient presents with a blood pressure of 160/78 following a liver transplantation. He's been taking prednisone since the transplantation to prevent rejection of his new liver, but now he is hypertensive. What is the cause of his hypertension?

A. Prednisone-induced upregulation of α1-receptors on arterioles

B. One of the general effects of immunosuppresion is hypertension

C. Prednisone-induced increase in cardiac output caused by stimulation of β1-receptors on cardiac muscle

D. ↑ plasma Ca+ levels caused by prednisone

E. None of the above
prednisone induced upregulation of alpha 1 receptors
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Old 08-05-2011
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Quote:
Originally Posted by ricko335 View Post
A patient presents with a blood pressure of 160/78 following a liver transplantation. He's been taking prednisone since the transplantation to prevent rejection of his new liver, but now he is hypertensive. What is the cause of his hypertension?

A. Prednisone-induced upregulation of α1-receptors on arterioles

B. One of the general effects of immunosuppresion is hypertension

C. Prednisone-induced increase in cardiac output caused by stimulation of β1-receptors on cardiac muscle

D. ↑ plasma Ca+ levels caused by prednisone

E. None of the above


i think...E....none of above...bcoz prednisone cause hypertension by water and sodium retention!!!
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Old 08-05-2011
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A,prednisone induced up regulation of alpha-1 receptors
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Old 08-05-2011
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Default Corticosteroids and Adrenergic alpha receptors

Corticosteroids have a permissive effect on alpha adrenergic stimulation by increasing the expression of alpha1-receptors, leading to hypertension in Cushing's patients.
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Old 08-05-2011
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prednisone withdrawal using cyclosporine monotherapy late after liver transplantation does not lead to graft loss and decreases the prevalence of diabetes, hypertension, and hypercholesterolemia. Symptoms occurring during withdrawal may be minimized by earlier or slower tapering.

source : ncbi.nlm.nih.gov/pubmed/8985286
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Old 08-05-2011
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E. None of the above ----> Cortisol main role is to maintain receptor sensitivity without it the adrenergic receptrs will desensitize. It also increase salt and water reabsortion in the kidney
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Old 08-07-2011
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the answer is a
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