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Old 08-08-2011
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A 7-year-old male is playing in a soccer game when he suddenly has difficulty breathing. The coach quickly realizes his player is having an asthmatic exacerbation and suspects that air pollen as the inciting cause. Which of the following cell types is involved in producing the immunoglobulin responsible for the child’s symptoms?
A. CD 8+ t cell
B. Cytotoxic T cell
C. T helper cell 2
D. T helper cell 1
E. Macrophage
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Old 08-08-2011
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Quote:
Originally Posted by ricko335 View Post
A 7-year-old male is playing in a soccer game when he suddenly has difficulty breathing. The coach quickly realizes his player is having an asthmatic exacerbation and suspects that air pollen as the inciting cause. Which of the following cell types is involved in producing the immunoglobulin responsible for the child’s symptoms?
A. CD 8+ t cell
B. Cytotoxic T cell
C. T helper cell 2
D. T helper cell 1
E. Macrophage
which q bank did you find this question?
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mike world
usmle step secrets q bank
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Old 08-08-2011
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Quote:
Originally Posted by ricko335 View Post
A 7-year-old male is playing in a soccer game when he suddenly has difficulty breathing. The coach quickly realizes his player is having an asthmatic exacerbation and suspects that air pollen as the inciting cause. Which of the following cell types is involved in producing the immunoglobulin responsible for the child’s symptoms?
A. CD 8+ t cell
B. Cytotoxic T cell
C. T helper cell 2
D. T helper cell 1
E. Macrophage
Th2 cells involved in formation of sensitized IgE which later trigger reaction on secondary xposure
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Old 08-08-2011
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c) T2 helpers through IL4 and 5 increase B cell reaction
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Old 08-09-2011
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it should technically be t2 cells, as they activate B cells, and hence the production of IgE.

o yes and just a re-call point: Rem. Mast cells produce IgE, eosinophils just respond to it.
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Correct Answer

The correct answer is C.
Asthma, which can be exacerbated by pollen, is mediated by the immunoglobulin IgE. In asthma, signaling by TH2 cells modulate the types of antibodies produced such that IgE production is favored over IgG. Allergens can be defined as antigens that trigger this type of antibody modulation.

TH1 cells produce IL-2, IFN (interferon)-α and tumor necrosis factor-alpha. CD8+ T cells lead to the formation of cytotoxic T cells, which ultimately activate macrophages and other CD 8+ T cells.
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Old 08-09-2011
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Th2 cells: because Th2 cells secrete IL-4 and thus help B cells class switch and produce IgE. IgE can then cross-link onto mast cells and produce asthmatic symptoms.

Please correct me if i am wrong. thank you.
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