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Old 08-08-2011
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Default exudation

A research scientist is attempting to develop a drug that interferes with fluid exudation during inflammation. He is focusing on the first event in fluid exudation. Which of the following is the first event of fluid exudation that he should focus on?
A. Arteriolar vasoconstriction
B. Dilatation of capillaries
C. Dilatation of arterioles
D. Widening of interendothelial gaps
E. Dilatation of postcapillary venules
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D) widening of interendothelial gaps
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Old 08-08-2011
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Quote:
Originally Posted by ricko335 View Post
A research scientist is attempting to develop a drug that interferes with fluid exudation during inflammation. He is focusing on the first event in fluid exudation. Which of the following is the first event of fluid exudation that he should focus on?
A. Arteriolar vasoconstriction
B. Dilatation of capillaries
C. Dilatation of arterioles
D. Widening of interendothelial gaps
E. Dilatation of postcapillary venules
widening of inter endothelial capi ?making the capillaries leaky
good q!
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Old 08-08-2011
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D.widening of interendothelial gaps.
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Default A)Arteriolar vasocontriction

Quote:
Originally Posted by ricko335 View Post
A research scientist is attempting to develop a drug that interferes with fluid exudation during inflammation. He is focusing on the first event in fluid exudation. Which of the following is the first event of fluid exudation that he should focus on?
A. Arteriolar vasoconstriction
B. Dilatation of capillaries
C. Dilatation of arterioles
D. Widening of interendothelial gaps
E. Dilatation of postcapillary venules

Arteiolar vasoconstriction is the first event in the stages of inflammation,followed by vasodilation,widening of gaps and exudation..

REF goljan rr 3 rd edition
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Originally Posted by drgsarunprasath View Post
Arteiolar vasoconstriction is the first event in the stages of inflammation,followed by vasodilation,widening of gaps and exudation..

REF goljan rr 3 rd edition
I don't think that's what its asking, its asking mechanism behind the edema, which isn't VC (that's would essentially decrease the edema)
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Default Actually its the sequential events of aacute inflammation

[QUOTE=patelMD;59616]I don't think that's what its asking, its asking mechanism behind the edema, which isn't VC (that's would essentially decrease the edema)


I need you to check RR goljan 3 ed pg no 21(if u have one) , under sequential events in acute inflammation

It is common to think straight way that there wud be vasodilation and increase in permeability of the vessel, but intial event is actually vasoconstriction whch many wudnt know..I know this because i asked this same question to a friend of mine while i was studying..

Please refer and get back to me doc
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[QUOTE=drgsarunprasath;59620]
Quote:
Originally Posted by patelMD View Post
I don't think that's what its asking, its asking mechanism behind the edema, which isn't VC (that's would essentially decrease the edema)


I need you to check RR goljan 3 ed pg no 21(if u have one) , under sequential events in acute inflammation

It is common to think straight way that there wud be vasodilation and increase in permeability of the vessel, but intial event is actually vasoconstriction whch many wudnt know..I know this because i asked this same question to a friend of mine while i was studying..

Please refer and get back to me doc
Yes I agree with you, it is VC at the very beginning, then VD, followed by all the other steps (rolling and adhesion, emigration etc.) But what causes the fluid transudation is the widening of the endothelial gaps which will allow plasma as well as WBC's to "leak".

Let's see what the answer is!
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I agree

D.widening of interendothelial gap
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Old 08-09-2011
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Shouldn't arteriolar vasodilation be the first event in fluid exudation? it increases the hydrostatic pressure, which is essential for pushing the transudate/exudate into interstitial tissue. vasoconstriction (first vascular event) doesn't really affect the whole process. but again that's what i think, correct me if i'm wrong.
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Vasoconstriction, that is the first thing that occurs for a split second, then you have vasodilation.
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Vasoconstriction, that is the first thing that occurs for a split second, then you have vasodilation.

exactly, and since the qn is "Which of the following is the first event of fluid exudation that he should focus on?" the vasoconstriction is unlikely to be the answer.
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Dilatation of Capillaries
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Correct Answer

The correct answer is A.
The fluid exudation of inflammation begins with a brief period of arteriolar vasoconstriction, followed shortly by dilatation of arterioles, capillaries and postcapillary venules. Fluid exudation may also be caused by endothelial injury or contraction of endothelial cells in postcapillary venules, with widening of inter-endothelial gaps.
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Default only we both got it right :)

Quote:
Originally Posted by USMLE2011m View Post
Vasoconstriction, that is the first thing that occurs for a split second, then you have vasodilation.

Its about the sequential of events in acute inflammation...
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Originally Posted by ricko335 View Post
The correct answer is A.
The fluid exudation of inflammation begins with a brief period of arteriolar vasoconstriction, followed shortly by dilatation of arterioles, capillaries and postcapillary venules. Fluid exudation may also be caused by endothelial injury or contraction of endothelial cells in postcapillary venules, with widening of inter-endothelial gaps.
Must have gotten confused with the question form oh, well...
thank you for the question.
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