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Old 11-24-2014
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Fire Thread Niacin excess

How does Niacin overdose cause hyperglycemia and hyperuricemia???i need pathophysiology behind this.plsssssss id joep4u13...
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Old 11-24-2014
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I searched that some while ago and the only thing I found was that Niacin through an unknown mechanism decreases the insulin sensitivity.

Also it binds to a Gi receptor in adipose tissue > decreases cAMP > decreases hormone sensitive lipase activity.
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