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Old 08-11-2011
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Question Oncogenic Angiogenesis Factor

Which of the following substances contributes most to blood vessel development in a tumor ?

A) IL-1
B) INF-Y
C) Epidermal Growth Factor
D) Fibroblast Growth Factor
E) Somatomedin C
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Old 08-11-2011
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Fibroblast growth factor
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Old 08-11-2011
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D. Fibroblast GF
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D) fibroblast growth factor!!!!
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I agree D) Fibroblast Growth Factor

The correct answer is D) Fibroblast Growth Factor.

Explanation-

Angiogenesis is driven by two substances - Vascular Edothelial Growth Factor (VEGF) and Fibroblast Growth Factor-2 (FGF-2). Their functions are as follows-
  • VEGF - increases endothelial cell motility & proliferation which causes new capillaries to sprout.
  • FGF-2 - promotes endothelial cell proliferation, migration & differentiation. It also plays an important role in embryogenesis by stimulating angioblast production, hematopoiesis & wound repair.

The other options are proinflammatory cytokines like IL-1 & INF-Y, which can INDIRECTLY promote angiogenesis through increased VEGF expression.

Also to remember, Laminin in the basement membrane can pose as physical barrier to the sprouting of new capillaries.
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Old 08-12-2011
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D) Fibroblast Growth Factor
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