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Old 08-12-2011
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Biochemistry Biotin as cofactor for which biochemical reactions!

A child presents with hair loss, skin, rashes, and exaggerated acidosis after infections. The child is found to have deficiency of biotinidase, and improves dramatically with biotin therapy. Biotin is involved in which of the following types of reactions?
a. Hydroxylations
b. Carboxylations
c. Decarboxylations
d. Dehydrations
e. Deaminations
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Old 08-12-2011
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b) Carboxylations


All CARBOXYLASE enzymes use ABC -
  • A- ATP
  • B- BIOTIN
  • C- Carbon Dioxide (CO2)
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Old 08-12-2011
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B) Carboxylations
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Old 08-13-2011
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b) Carboxialtions:
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Old 08-13-2011
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biotin is used in 3 carboxylation enzymes!
1- pyruvate caroxylase
2-acytyl coA carboxylase
3- propionyl coA caroxylase
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sure its B ... biotin required for ABC enzymes .. carboxylases which require ATP,BIOTIN,CO2,
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Old 08-13-2011
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B.carboxylation
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Old 08-14-2011
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Carboxylations
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