Chronic Renal Failure as cause of Secondary Hyperaldosteronism? - USMLE Forums
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Old 08-14-2011
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Kidney Chronic Renal Failure as cause of Secondary Hyperaldosteronism?

Hey guys,
I have this doubt. FA says that Chronic renal failure (CRF) causes secondary hyperaldosteronism due to kidney perception of low intravascular volume resulting in overactive renin-angiotensin system. (FA 2010 pg 291).
But we all know that CRF is a common cause of hyperkalemia in which the mechanism appears to be a deficient renin production by the damaged kidney, which in turn causes lower than normal secretion of aldosterone by the adrenal cortex. What am i missing here? I can understand that renal artery stenosis, CHF and cirrhosis can produce secondary hyperaldosteronism, but how can CRF produce secondary hyperaldosteronism?
Please someone, thanx.
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