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Old 08-14-2011
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Default Cartilage Growth in vitro

A physician-scientist is conducting an experiment in which she tries to stimulate growth of cartilage in vitro. She wishes to use a substance to stimulate histogenesis. Which substance would be best suited to her purposes based on its stimulation of cartilage growth in vivo?



A. Cortisone
B. Estrogen
C. Thyroxine
D. Vitamin A
E. Vitamin D
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B. Estrogen
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Old 08-14-2011
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b) estrogen - acts to growth plate
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Old 08-14-2011
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Default The answer was Thyroxine..

The answer to this question was thyroxine but there wasnt a explanation,can someone could

explain plz,What are we missing here !!!
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Quote:
Originally Posted by drgsarunprasath View Post
The answer to this question was thyroxine but there wasnt a explanation,can someone could

explain plz,What are we missing here !!!
I suspect that its because thyroxine is involved in bone growth (hypothyroid in child can cause short stature because liner bone growth involves cartilaginous bone to form followed by replacement with woven bone) so it might have same FGF 2 / IGF stimulating properties as other anabolic hormones.

Just a thought tho, no idea otherwise.
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Default Good explanation,i thought the same too

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Originally Posted by patelMD View Post
I suspect that its because thyroxine is involved in bone growth (hypothyroid in child can cause short stature because liner bone growth involves cartilaginous bone to form followed by replacement with woven bone) so it might have same FGF 2 / IGF stimulating properties as other anabolic hormones.

Just a thought tho, no idea otherwise.

Does some one have other ideas !!!!
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Old 08-15-2011
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Originally Posted by drgsarunprasath View Post
Does some one have other ideas !!!!
estrogen stops the bone growth by early closing the metaphysis with epiphysis so it cant be the ans...
so the only reason for thyroxine to be true should be becuase thyroxine is like the base for all the hormones. in order to make other hormones work, we have to have thyroxine..!
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