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Old 08-14-2011
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Neuro Gigantic deformed astrocytes and oligodendrocytes with abnormal nuclei

A 38 year old woman with a 15 year history of drug abuse who is being treated for fever, cough, and shortness of breath, develops dementia, hemiparesis, ataxia, aphasia, and dysarthria over the course of 5 days. MRI reveals multiple white matter lesions. Over the course of 2 weeks, the woman's condition worsens, Despite aggressive treatment, she lapses into a coma and soon dies. At autopsy, histologic examination of her brain tissue reveals gigantic, deformed astrocytes and oligodendrocytes with abnormal nuclei.

What is the most likely cause of this woman's CNS symptoms?

A. Autoimmune attack of myelin sheaths
B. A double-stranded circular DNA virus
C. A single-stranded linear RNA virus
D. An autosomal recessive lysosomal storage disease
E. A proteinaceous infectious particle
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Old 08-14-2011
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E. A proteinaceous infectious particle
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A. Autoimmune attack of myelin sheaths ?
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B. A double-stranded circular DNA virus
I think it is cytomegalovirus in AIDs patient due to drug abuse
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Old 08-14-2011
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a dsDNA circular virus
polyoma virus attacks oligodendrocytes n astrocytes producing demyelination
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Old 08-14-2011
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EE. A proteinaceous infectious particle
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Old 08-14-2011
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c) HIV - encephalitis;
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Old 08-14-2011
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E.proteinaceous infectious particles
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Old 08-14-2011
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Quote:
Originally Posted by qurat21 View Post
a dsDNA circular virus
polyoma virus attacks oligodendrocytes n astrocytes producing demyelination
I agree, I think it's progressive multifocal leukoencephalopathy
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Old 08-14-2011
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Post C

C. A single-stranded linear RNA virus

Rabies?
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Old 08-14-2011
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Its b.pml by jc viruse
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Old 08-14-2011
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i think its B JC
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Old 08-14-2011
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Default B)ds circular DNA

It is PML caused by JC virus in a pt with HIV,risk factor being IV drug

absuse,other clue is rapid detoriation of the patient symptoms.
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Old 08-15-2011
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Quote:
Originally Posted by drgsarunprasath View Post
a 38 year old woman with a 15 year history of drug abuse who is being treated for fever, cough, and shortness of breath, develops dementia, hemiparesis, ataxia, aphasia, and dysarthria over the course of 5 days. Mri reveals multiple white matter lesions. Over the course of 2 weeks, the woman's condition worsens, despite aggressive treatment, she lapses into a coma and soon dies. At autopsy, histologic examination of her brain tissue reveals gigantic, deformed astrocytes and oligodendrocytes with abnormal nuclei.

What is the most likely cause of this woman's cns symptoms?

A. Autoimmune attack of myelin sheaths
b. A double-stranded circular dna virus
c. A single-stranded linear rna virus
d. An autosomal recessive lysosomal storage disease
e. A proteinaceous infectious particle
eeeeeeeeeeeeeeeeeee
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