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Old 08-14-2011
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Default Intracellular calcium

Increases in intracellular calcium can be especially detrimental to the cell. Therefore, calcium homeostasis is very tightly regulated not
only across the cell membrane but also through the additional work of sequestration in endoplasmic reticulum and mitochondria. In which of the following ways does increased intracellular calcium concentration cause themost cell damage?


(A) Enzyme activation
(B) Free radical generation
(C) Increased membrane permeability
(D) Inhibition of glycolysis
(E) Inhibition of oxidative phospho

Last edited by drgsarunprasath; 08-14-2011 at 11:07 AM.
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Old 08-14-2011
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(C) Increased membrane permeability
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A) Enzyme Activation
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Old 08-14-2011
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yes I also think its A)

It'll activate casper the friendly ghost.
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Old 08-14-2011
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a) for sure activator of caspases
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A.enzyme activation
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Old 08-14-2011
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Where can I read more on this process?
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Quote:
Originally Posted by usluipek View Post
Where can I read more on this process?
Goljan RR; necrosis.
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Default A)Enzyme activation

Activates enzymes such as Caspases,cytrochrome c.etc.....
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A enzyme activation
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Old 08-15-2011
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when there is dec O2, intracellular Ca activates 3 enzymes:
1- phospholipase that inc cellular permeabilty
2-protease that breaks down proteins
3-endonuclease that cause pyknosis
so ans is A!
but there is one more function.. it also inc reentry of ca in mitochondria and inc permeabilty and also activates cytochrome c which cause apoptosis!
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