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Old 08-15-2011
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A patient with nodular sclerosing Hodgkin’s lymphoma is treated with a chemotherapeutic agent that carries a potential side effect of pulmonary fibrosis. Which is involved in the mechanism of action for this agent?
A. Tubulin
B. Superoxide
C. Glucocorticoid
D. Human epidermal growth factor receptor 2
E. Alkylated guanine
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Old 08-15-2011
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A. Tubulin, bleomycin on G2 phase
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Old 08-15-2011
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Correct Answer

Quote:
Originally Posted by pass7 View Post
A. Tubulin, bleomycin on G2 phase
drugs causing pulmonary fibrosis are
amiodarone
bleomycin, busulfan
cyclophosphamide
MTX, methysergide
Nitrofurontoin, nitrosurea
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Old 08-16-2011
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The correct answer is B.
One of the regimens used to treat Hodgkin’s is ABVD: adriamycin (doxorubicin), bleomycin, vinblastine and dacarbazine. Of these, bleomycin is known to have pulmonary fibrosis as a side effect. The mechanism of action of bleomycin is the chelation of metal ions to produce superoxide and hydroxyl free radicals, which break DNA.
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