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Old 08-15-2011
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Default amlodipine-kind calcium channel blockers

Hi all:

I have a question. If amlodipine-kind calcium channel blockers mainly work on arterial smooth muscles. Why there is side effects like peripheral edema and flushing? I thought peripheral edema and flushing are due to venous dilation.

Besides, the reason that nifedipine is contraindicated in cases of recent myocardial infection or stable angina is because nifedipine dilates veins, and this decreases preload and subsequently leads to refelx tachycardia. Reflex tachycardia is bad for patiens with recent myocardial infection or stable angina.

If dipine-like calcium channel blockers only work on the artery, why there is peripheral edema and flushing, are they due to arterial dilation? And if they only work on the artery, why nifedipine is contrindicated for recent myocardial infection or stable angina?

Please help me explain these two points, thank you.

Last edited by chienpolska; 08-15-2011 at 09:41 AM.
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