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Old 08-15-2011
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Default urine on standing

A 19-year-old female visits her primary care provider because she is experiencing burning on urination. Her physician orders a routine urinalysis to confirm the urinary tract infection, but notices that the sample turned black before it was sent to the lab. Based on this observation, what additional molecule should the sample be tested for?
A. Homocysteine
B. Urea
C. Uric acid
D. Phenylacetate
E. Homogentisate
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Old 08-15-2011
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Originally Posted by ricko335 View Post
A 19-year-old female visits her primary care provider because she is experiencing burning on urination. Her physician orders a routine urinalysis to confirm the urinary tract infection, but notices that the sample turned black before it was sent to the lab. Based on this observation, what additional molecule should the sample be tested for?
A. Homocysteine
B. Urea
C. Uric acid
D. Phenylacetate
E. Homogentisate
E. Homogentisate

Case of: Alkaptonuria
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E) Homogentisate
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Old 08-16-2011
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Correct Answer

The correct answer is E.
A urine sample that turns black when left sitting strongly suggests alkaptonuria. While the patient may well have a UTI, this could be a more significant finding. Alkapton, more commonly referred to as homogentisate, accumulates because of deficient HDG (homogentisic acid dioxygenase
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