Why piperacillin/tazobactam and imipenem is not good! - USMLE Forums
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Old 08-15-2011
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Drug Why piperacillin/tazobactam and imipenem is not good!

OT is a 16-year-old boy who is diagnosed with ALL Five days after induction chemotherapy, OT develops a fever to 101"F and chills. His ANC is < 500/uL. Overnight the cross-over team started piperacillin/tazobactam and imipenem. This regimen is not ideal for which of the following reasons?
A. Similar adverse event profile
B. Potential for antagonism
C. Imipenem is inactivated by tazobactam
D. Overlapping spectrum of activity
E. Both are excreted by the kidney
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  #2  
Old 08-15-2011
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Ddddddddddddddddd?
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  #3  
Old 08-16-2011
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my ans is C!
imipenem is Beta lactamase resistent but tazobactam is beta lactamase
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Old 08-16-2011
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Guessing E???
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  #5  
Old 08-16-2011
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B. Potential for antagonism
as
. Carbapenems are unsuitable in
combination with another beta-lactam because they are potent
inducers of beta-Iactamases
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Old 08-16-2011
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D..similar spectrum
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