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Old 08-16-2011
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Anesthesiology Thiopental versus Propofol

Patients are maintained at the same depth of anesthesia by infusion of either thiopental or propofol. A graph (not displayed) shows that the recovery time for thiopental is greater than propofol. Which of the following characteristics of thiopental, but not propofol, best explains the difference between these two drugs?

A) Distribution of thiopental into adipose tissue
B) First-order hepatic elimination of propofol
C) Saturable renal clearance of thiopental
D) Tolerance of propofol in the central nervous system
E) Zero-order metabolic elimination of thiopental
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Old 08-16-2011
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is it B).??
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Old 08-16-2011
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I would guess A)

if its more soluble, it will redistribute into fat.
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Old 08-16-2011
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Quote:
Originally Posted by patelMD View Post
I would guess A)

if its more soluble, it will redistribute into fat.
but then the recovery time from anaesthesia shud be less, because it would be cleared off the blood quicker..(actually this does happen wid thiopental, but the que says recovery time for thiopental is more then propofol)
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Old 08-16-2011
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Originally Posted by drnirajmavani View Post
but then the recovery time from anaesthesia shud be less, because it would be cleared off the blood quicker..(actually this does happen wid thiopental, but the que says recovery time for thiopental is more then propofol)
Exactly, because once its in fat, where will it come back out to once the concentration in blood goes down? .. Blood! So it will still be there until it is completely eliminated therefore increased recovery time.
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Old 08-16-2011
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Originally Posted by patelMD View Post
Exactly, because once its in fat, where will it come back out to once the concentration in blood goes down? .. Blood! So it will still be there until it is completely eliminated therefore increased recovery time.
i think recovery refers to brain coming out of anaesthesia, nd after redistribution into fat, i agree it would com back in blood, bt do u mean to say concentration would go high enough to produce anaesthesia again after the recovery?if no, thn recovery tim shud be decreased nd not increased
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Old 08-16-2011
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Default correct answer EE

yes you r right the answer is EE,
but can you please explain,
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