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Old 08-16-2011
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Default blood gases

In the operating room, a patient with known G6PD deficiency becomes hypoxic after administration of a sulfa antibiotic. Despite increasing oxygenation, the pulse oximeter maintains a reading of 85%. The patientís arterial blood has a chocolate brown appearance. Which of the following drugs can treat this condition?
A. Fresh Frozen Plasma
B. Thiosulfate
C. Heparin
D. Bicarbonate
E. Methylene blue
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Old 08-16-2011
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E) methylene blue....bcoz patient has methemoglobinemia:sorry:
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E. Methylene blue
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Old 08-18-2011
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The correct answer is E.
Patients with G6PD deficiency are prone to developing methemoglobinemia after insults with different types of drugs. These patients have an impaired production of cofactor NADPH, involved in the protective actions of NADH methemoglobin reductase enzyme. This protective enzyme defends against oxidative stress by counteracting the conversion of (Fe2+ ferrous) hemoglobin to (Fe3+ferric) methemoglobin.
Meth hemoglobin is unable to bind to oxygen. Methylene blue restores the iron in hemoglobin to the normal, reduced Fe 2+ oxygen carrying state.
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