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Old 12-08-2014
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Default what makes negative symptoms of schizophrenia : high serotonin or low serotonin ?

i know , maybe it is stupid question, and dont blame me . i have also viewed wikipedia but couldnt find answer for this . maybe i have missed something . so , i am doing pharm kaplan . kaplan video says that schizophrenics have dopamine and serotonine balance => high DA and low SEROTONIN . so we must make DA low and make SE high . we reduce DA by inhibition of DA receptors , and elevate SE by inhibiting 5ht-2 receptors . video says, that 5-ht2 is presynaptic, and inhibiting of it we increase of SE release . is it true ? but one man , who have passed steps and have been enrolled into residency in usa says that schizophrenycs have high DA and high SE , and inhibiting 5ht-2 we are making low the action of SE. and some web sites i have found , say that schizophrenycs have high SE . which one is true ?
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Old 12-08-2014
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Originally Posted by elMuchacho View Post
i know , maybe it is stupid question, and dont blame me . i have also viewed wikipedia but couldnt find answer for this . maybe i have missed something . so , i am doing pharm kaplan . kaplan video says that schizophrenics have dopamine and serotonine balance => high DA and low SEROTONIN . so we must make DA low and make SE high . we reduce DA by inhibition of DA receptors , and elevate SE by inhibiting 5ht-2 receptors . video says, that 5-ht2 is presynaptic, and inhibiting of it we increase of SE release . is it true ? but one man , who have passed steps and have been enrolled into residency in usa says that schizophrenycs have high DA and high SE , and inhibiting 5ht-2 we are making low the action of SE. and some web sites i have found , say that schizophrenycs have high SE . which one is true ?

Forget about what did you read on Wiki, Watched Youtube or heard from your God Damn Resident in the US => keep it straight - DA is high - positive symptoms ( gallusinations) , 5HT is low (amotivation, depressed)
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Old 12-08-2014
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thanks friend . now i can sleep . i must just memorize those drugs and it is okay now and what about receptors 5ht2 ? do they make serotonin low ? and inhibiting them with clozapine , we get elevation of serotonin ?
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Old 01-22-2015
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I have the same doubt same as ELMUCHACHO ....SEARCHED on wiki n etc about atypicals. does blocking 5ht2 receptors increases serotonin or decrease?? and also uworld says treatment of serotonin syndrome is cryptoheptadine a non specific 5ht1 and 5ht2 receptor antagonist with anti serotogenic properties . now by blocking 5ht2 receptors r we increasing serotonin[ as said in kaplan videos stating its a alpha2 type presynaptic inhibition] or blocking 5ht2 decreases serotonin .please help
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Old 01-22-2015
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hello. so i just decided to memorize like this: schizophrenia has high dopamine and low serotonin . to treat it we must block both D and H2 receptors , blocking D will decrease effect of Dopamine , and consequently blocking H1 will increase Serotonin( !!not decrease!! ) . maybe it is like A2 receptors , when we stimulate it , we decrease effect of Norepinephrine , and so reversely . it seems that only thing that we should know , is to block dopamine and serotonin receptors for schizophrenia treatment , thats all
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