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Old 08-18-2011
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Help some confusion regarding thalassemia..

I want to clear some confusion regarding thalassemias..
How RBC count is increased in it?
Is it in beta thalassemia minor only?...due to increase synthesis of HbA2.
or does the RBC count is increased in Thalassemia major also??

Any help??
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Old 08-18-2011
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we know in thallasemia there is alot of extravascular hemolysis going on by spleen so bone marrow tries to compensate it and basic rule whenever u have severe hemolysis u get increased reticulocytes count .. thats why reticlulocytosis occur in thallasemia ... simple dude:P
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Old 08-18-2011
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Default hi

hi,
i don't really understand the question but i have checked it up a bit.
i didn't know that thalassemia causes increased rbc count, i always thought it causes the opposite.
all thalassemia should have anemia, but the severity of anemia depends on the type of thalassemia, the more genes deleted the more severe the anemia.
in B thal major no B chain is produced so there are two alpha chains that cannot be paired with B to give normal HB, instead there is more production of gamma chain so that Hb F is increased (also in B thal minor)
in addition in B thal minorHbA2 production is increased since delta chains are made to match the alpha chains.
i don't feel that i have answered your question but this is almost all i know about thal.
pls kindly let me know the source where you found that rbc count is increased in thal.
thanks
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Old 08-18-2011
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Quote:
Originally Posted by nativedoc View Post
hi,
i don't really understand the question but i have checked it up a bit.
i didn't know that thalassemia causes increased rbc count, i always thought it causes the opposite.
all thalassemia should have anemia, but the severity of anemia depends on the type of thalassemia, the more genes deleted the more severe the anemia.
in B thal major no B chain is produced so there are two alpha chains that cannot be paired with B to give normal HB, instead there is more production of gamma chain so that Hb F is increased (also in B thal minor)
in addition in B thal minorHbA2 production is increased since delta chains are made to match the alpha chains.
i don't feel that i have answered your question but this is almost all i know about thal.
pls kindly let me know the source where you found that rbc count is increased in thal.
thanks

You can look it in Golajn RR..page no 205..table # 11-2
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Old 08-19-2011
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Quote:
Originally Posted by struggle View Post
You can look it in Golajn RR..page no 205..table # 11-2
what i have described above is said by goljan in his audio lectures ..basically reticulocytosis occur which are immature small RBCs
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Old 08-19-2011
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i checked up goljan.. in the text it says..

b thal minor has increased RBC count

b thal major has increased Reticulocyte count

there isn't an explanation regarding this.. but this is my logic (not sure if i'm right) - since b thal minor is a relatively milder form of the disease, more reticulocytes progress to RBCs before being hemolyzed whereas in b thal major, which represents a more severe form of hemolysis (due to complete absence of the b globin chain) they get hemolyzed sooner.. therefore accounting for lower RBC and greater retics count.

does this make sense?
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Old 08-19-2011
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Quote:
Originally Posted by ispy View Post
i checked up goljan.. in the text it says..

b thal minor has increased RBC count

b thal major has increased Reticulocyte count

there isn't an explanation regarding this.. but this is my logic (not sure if i'm right) - since b thal minor is a relatively milder form of the disease, more reticulocytes progress to RBCs before being hemolyzed whereas in b thal major, which represents a more severe form of hemolysis (due to complete absence of the b globin chain) they get hemolyzed sooner.. therefore accounting for lower RBC and greater retics count.

does this make sense?
yup u are right whenever we have severe hemolysis as in colleys anemia thallasemia major we got very much increased rreticulocytes count goljan said that in audio lectures
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