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Old 08-21-2011
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Microscope Defective Blood-Testis Barrier!

An 18-year-old male is found to have a rare autoimmune disorder where his immune system attacks his own sperm. Laboratory analysis shows he has a defective blood-testis barrier thus allowing antibodies to pass and attack his sperm. Which of the following epithelial cell junctions is most likely affected in the blood-testis barrier?

A. Integrins
B. Tight junctions
C. Desmosomes
D. Connexons
E. Hemidesmosomes
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Old 08-21-2011
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ans B. tight junctiion..
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Old 08-21-2011
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Tight junction it seems but not sure
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Old 08-21-2011
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obviously it seems dt tight junctions between sertoli cells of testis are gonna to be affected::%%
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Old 08-21-2011
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tight junctions...
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Old 08-21-2011
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it should b B bood testis barrier and blood brain barrier tight junctions are involved in both simple thing ..... and rest of things integrins defect in LAD deficiency , antibody against desmosomes in pemphigus vulgaris , antibody against hemidesmoses in bullous pemphigoid,
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Old 08-21-2011
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B. Tight junctions
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Old 08-21-2011
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tight junctions
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Old 08-21-2011
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blood testis barrier is formed by tight junctions
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Old 08-22-2011
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The correct answer is B.
Tight junctions between Sertoli cells form the blood-testis barrier. Desmosomes are the most common type of intercellular junction. Connexons directly connect the cytoplasm of two cells, which allows various molecules and ions to pass freely between cells to perform metabolic and electric functions. Hemidesmosomes are similar in appearance to desmosomes. Rather than linking two cells, hemidesmosomes attach one cell to the extracellular matrix. Rather than using cadherins, hemidesmosomes use integrin cell adhesion proteins. Integrins are cell surface receptors that interact with the extracellular matrix (ECM). They bind to lamin in the basement membrane
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