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  #1  
Old 08-27-2011
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Default lipids biochemistry mcq

An 11 year old boy presents with balance and difficulty with night vision. His mother says he had foul smelling stools and failure to thrive as an infant. Physical examination reveals poor muscle coordination, ataxia, decreased proprioception and vibratory sensation. Lab tests show low total cholesterol and Vitamin A levels. The patient most likely has an inherited mutation in which of the following?
a. 7- alpha hydroxylase
b. Microsomal Transfer Protein (MTP)
c. Hormone Sensitive Lipase (HSL)
d. Lipoprotein Lipase (LPL)
e. Lecithen Cholesterol acetyltransferase (LCAT)
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  #2  
Old 08-27-2011
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Listening lipids biochem mcq

I think it is(b) Microsomal transfer protein
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  #3  
Old 08-27-2011
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Default

thinking a
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  #4  
Old 08-27-2011
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Default a.

a.7 alpha hydroxylase, is the rate limiting enzyme for biliary acid synthesis, which is needed for fat absorption, in this case affecting fat soluble vitamins A and E.
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Old 08-27-2011
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Correct Answer

LPL def causes acute pancreatitis.. pancreatitis causes Malabsorption and fat soluble Vit def.. and foul smell..
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Default C?

hormone sensitive lipase??????????
ans pls:sorry:
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  #7  
Old 08-28-2011
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Correct Answer The correct answer is B microsomal transfer protein

this patient has abetalipoproteinemia due to mutation in microsomal triglyceride trasfer protein gene ( MTTP) that is impotant for the ability of apolipoprotein B whether B48 to chylomicron or B100 to VLDL which will lead to abetalipoproteinemia with low serum levels of cholesterol and vit A which is fatsoulable vitamin
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