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Old 01-05-2015
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Default contraction alkalosis

can anyone explain to me about contraction alkalosis??
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Old 01-06-2015
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vomiting, loop or thiazide diuretics,hyperaldosteronism r common causes of metabolic alkalosis.out of these vomiting and loop or thiazides lead to contraction alkalosis as volume is depleted.
decrease in ecf vol itself causes alkalosis as bicarb gets concentrated then other mechanisms set in like dec in ecf leads to dec renal perfusion,inc renin,inc AT II,inc aldosterone.ATII acts on Na+H+ anti port of pct & inc H+ secretion into lumen which inc bicarb reabsorption.Also aldosterone acts on H+ATPase pump of intercalated cells & H+K+ pump on principal cells of Dct and collecting duct inc H+ secretion thereby inc new bicarb reabsorption(whereas bicarb absorbed in pct is filtered not new one) further adding to alkalosis.

In vomiting (loss of Hcl) & thiazide or loop diuretics(loss of cl- in urine) there is volume & cl- depletion.so it is corrected by normalsaline where as hyperaldosteronism(not vol depleted no contraction alkalosis) not corrected by saline.
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Old 01-06-2015
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thanks a lot.
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