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  #1  
Old 08-31-2011
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Virus NBME 11 Concept Salk and Sabin Polio Vaccines

This question is testing the concept and not the exact question. Look away if you don't want to see it before you attempt the exam.

Which of the following is the common feature between Inactivated Polio virus vaccine(Salk) and Attenuated Polio virus vaccine (Sabin)?

a) Activated CD8 cytotoxic lymphocytes effectors in the circulation
b) Activated CD8 cytotoxic lymphocytes effectors in the gut
c) Neutralizing antibodies in the circulation
d) Neutralizing secretory IgA antibodies in the gut
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  #2  
Old 08-31-2011
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Default A?

A?

i choose A
i am thinking that any option which mentions 'gut' is wrong since sabin is the one that resembles naturally acquired polio the most.
i think viral infections are taken care of by cytotoxic T cells, now whether in the gut or blood, i think in the blood
answer pls
Quote:
Originally Posted by donofitaly View Post
This question is testing the concept and not the exact question. Look away if you don't want to see it before you attempt the exam.

Which of the following is the common feature between Inactivated Polio virus vaccine(Salk) and Attenuated Polio virus vaccine (Sabin)?

a) Activated CD8 cytotoxic lymphocytes effectors in the circulation
b) Activated CD8 cytotoxic lymphocytes effectors in the gut
c) Neutralizing antibodies in the circulation
d) Neutralizing secretory IgA antibodies in the gut
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donofitaly (09-01-2011)
  #3  
Old 08-31-2011
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Quote:
Originally Posted by donofitaly View Post
This question is testing the concept and not the exact question. Look away if you don't want to see it before you attempt the exam.

Which of the following is the common feature between Inactivated Polio virus vaccine(Salk) and Attenuated Polio virus vaccine (Sabin)?

a) Activated CD8 cytotoxic lymphocytes effectors in the circulation
b) Activated CD8 cytotoxic lymphocytes effectors in the gut
c) Neutralizing antibodies in the circulation
d) Neutralizing secretory IgA antibodies in the gut
sureeeeeeee its C ................. sorry i was in hurry that timee .. so did mistake in choosing option yeah its c coz both salk and sabin activate humoral immunity but only live vaccine can activate cell mediated immunity
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Last edited by yasirsattar75; 08-31-2011 at 06:36 PM.
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Old 08-31-2011
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Quote:
Originally Posted by yasirsattar75 View Post
sureeeeeeee its B .................
B is a feature of the oral polio vaccine only.
Answer should be C.
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Old 08-31-2011
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Quote:
Originally Posted by step1an View Post
B is a feature of the oral polio vaccine only.
Answer should be C.
yea my and my friend took this nbme...the answer is C, your right.....but i'm just wondering, why isnt it secretory IgA?
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Old 08-31-2011
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C). salk does not mimic an actual infection unlike sabin, so there are no antibodies in the gut ( which is the natural route of inf).
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Old 08-31-2011
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Quote:
Originally Posted by jattdoc View Post
yea my and my friend took this nbme...the answer is C, your right.....but i'm just wondering, why isnt it secretory IgA?
secretory IGA is for adenovirus vaccine .. as mentioned in kaplan
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Old 02-04-2012
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You missed out option C from the real question...
a) Activated CD8 cytotoxic lymphocytes effectors in the circulation
b) Activated CD8 cytotoxic lymphocytes effectors in the gut
c) CD8 memory cells...
d) Neutralizing antibodies in the circulation
e) Neutralizing secretory IgA antibodies in the gut

I thought both would activate CD8 cells, since for polysaccharide vaccines we combine it with toxoids to make them tcell dependent and stimulate memory cells...
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Old 03-05-2012
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Quote:
Originally Posted by hishamsalahuddi View Post
You missed out option C from the real question...
a) Activated CD8 cytotoxic lymphocytes effectors in the circulation
b) Activated CD8 cytotoxic lymphocytes effectors in the gut
c) CD8 memory cells...
d) Neutralizing antibodies in the circulation
e) Neutralizing secretory IgA antibodies in the gut

I thought both would activate CD8 cells, since for polysaccharide vaccines we combine it with toxoids to make them tcell dependent and stimulate memory cells...
This one is definitely wrong, cuz thats what I answered in the online form and saw it in the feedback.
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Old 03-05-2012
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i think its d..the circulating antibodies in the body...
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Old 03-05-2012
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Quote:
Originally Posted by yasirsattar75 View Post
secretory IGA is for adenovirus vaccine .. as mentioned in kaplan
secretory iga is case on oral polio vaccine..i am sure..its given in our counrty and have to learn extensively about it..but yup the IPV is not iga mediated...
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  #12  
Old 03-07-2012
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D
because secretory live vaccines 9 (eg OPV) directly stimulate mucosal surface and will produce more duodenal IgA than the inactivated vaccines (eg IPV)
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