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Old 09-01-2011
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Question NBME 12 Concept; Steroid binding to cellular component!

Guys the concept of one of the questions.
When you use dexamethasone to induce surfactant release. This dexamethasone is going to exert it's function by binding to??????

From FA because is a glucocorticoid I will say it acts on cytosolic receptor.
That was no on the answer choices so I picked Nuclear receptors and I have it right.

Why?????????

Is FA wrong??????
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Old 09-01-2011
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All glucocorticoids bind to nuclear receptors... That's weird that FA says that. Did you check in the errata list? What year are you using?
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Old 09-01-2011
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I just checked my FA 2010 and it's listed under steroid receptors under the endocrine section which means that it uses a nuclear receptor.
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Old 09-01-2011
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2011.
But in the FA says that they bind to cytosolic receptors.
Only T3 and T4 bind to nuclear receptors.
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Old 09-01-2011
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Quote:
Originally Posted by evavar View Post
2011.
But in the FA says that they bind to cytosolic receptors.
Only T3 and T4 bind to nuclear receptors.
In which section? Did you check where I'm telling you?
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Old 09-01-2011
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yep, endocrine section under the mnemonic VET CAP
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Old 09-01-2011
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Both these statements are right in a way.

Steroids bind to the cytosolic receptors whose active site is covered by Heat Shock protein HSP. When steroid binds to this cytosolic receptor, HSP is released. Now this Steroid-receptor becomes activated & moves inside the cell to start transcription by binding to various Transcription Factors (nuclear receptor)
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Old 09-01-2011
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That's the right answer, we have to know a few things, the only "Direct acting" on nuclear receptors are the T3/t4 but others steroids works by cytosolic receptor which onces they are activated by binding to a protein nuclear transpoter, they move into the nuclear...

In other way to see it, Is the same concept WHY Peptide hormone as faster than steroid... because "steroids needs those transport" to exert their effect while peptide hormone dont... =)

Keeping in mind that If we have to call it in some way, T3/t4 direct Nuclear receptor, Steroids Indirect... that's how i think about it.

Hope it helps...
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Old 09-01-2011
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Quote:
Originally Posted by evavar View Post
Guys the concept of one of the questions.
When you use dexamethasone to induce surfactant release. This dexamethasone is going to exert it's function by binding to??????

From FA because is a glucocorticoid I will say it acts on cytosolic receptor.
That was no on the answer choices so I picked Nuclear receptors and I have it right.

Why?????????

Is FA wrong??????
i missed that same que, cuz i choose microlamellar bodies as the ans as cytosolic receptors wer nt there in the ans...
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Old 09-11-2011
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Default nuclear receptors

yeah its nuclear receptor used by glucocorticoid as we know steroids are lipid soluble directly croses cell memberane and enter into cytosol and then into nucleus and in nucleus their it act as transcription factor having a DNA binding domain(zinc finger motiffs) that binds to HRE(hormone response elements on DNA) and causes increased expression of genes for e.g in case of gluconegenesis they increases expreession of PEPCK gene expression by binding to hormone response elements(GRE) ... hope its easy now ...
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