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Old 09-03-2011
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Question pco, dec aromatase or dec aromatase?

i read in goljan and uw that there is inc aromatase and thus there is increase esterogen and hence inc risk for endometrial ca.
but today i read in kaplan qbank that there due to dec FSH there is granulosa cell atrophy there is dec aromatase and thus esterogen is dec cuz androgens cannot aromatase into esterogen thus there is dec esterogen
if anyone has the concept, please explain!
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Old 09-03-2011
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I agree

ok so this is what i have concluded that androgens are aromatized by adipose tissue into esterogen but not by aromataze in the granulosa cell because granulosa cell is atrophied due to the lack of FSH
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Old 09-03-2011
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Quote:
Originally Posted by salz View Post
i read in goljan and uw that there is inc aromatase and thus there is increase esterogen and hence inc risk for endometrial ca.
but today i read in kaplan qbank that there due to dec FSH there is granulosa cell atrophy there is dec aromatase and thus esterogen is dec cuz androgens cannot aromatase into esterogen thus there is dec esterogen
if anyone has the concept, please explain!
what i understand from pos is that there is increased LH and decreased FSH so as we know LH stimulate theca interna cells that have desmolase activity that make androgens from cholesterol and as there is increased LH there is increased androgens which are aromatized by adipose tissue into estrogens and as we know estrogens have negative feedback on FSH (FSH normally stimulates granulosa cells that have aromatase activity for conversion to estrogens as there is dec FSH in POS so follicules undergo atresia thats why patients have anovulatory cyles also .. ) i hope it makes sense and its easy now
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