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  #1  
Old 09-04-2011
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Arrow Inc in 2,3BPG

during high altitude stay for long, causes the inc in 2,3 bisphophoglycerate and how does it help the hypoxi or dec pao2?
well the ans is simple and i jus read it in brs. that even 2,3 bisphophoglycerate has more affinity for beta portion of Hb than the O2, thus it cause the easy unloading of o2 from the Hb and making it possible for tissues to use this O2
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  #2  
Old 09-04-2011
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Originally Posted by salz View Post
during high altitude stay for long, causes the inc in 2,3 bisphophoglycerate and how does it help the hypoxi or dec pao2?
well the ans is simple and i jus read it in brs. that even 2,3 bisphophoglycerate has more affinity for beta portion of Hb than the O2, thus it cause the easy unloading of o2 from the Hb and making it possible for tissues to use this O2
yeah simple thing is 2.3bpg causes right shift of hemoglobin dissociation curve and all the things which causes right chift causes increased unloading of oxygen .. and yup u are right it crosslinks two beta chains of hemoglobin
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Old 09-05-2011
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Originally Posted by yasirsattar75 View Post
yeah simple thing is 2.3bpg causes right shift of hemoglobin dissociation curve and all the things which causes right chift causes increased unloading of oxygen .. and yup u are right it crosslinks two beta chains of hemoglobin
ok so my question to u is, what does it do to p50, and what is p50? and what is the diff between p50 and po2?
never mind, ill jus answer myself. lol
p50 is like 50 percent saturation of O2 with the Hb. means that when po2 is 25mmhg, the hb percent saturation is 50 percent.
and po2 is only the dissolved form of o2 in the blood. right?
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Old 09-05-2011
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Originally Posted by salz View Post
ok so my question to u is, what does it do to p50, and what is p50? and what is the diff between p50 and po2?
never mind, ill jus answer myself. lol
p50 is like 50 percent saturation of O2 with the Hb. means that when po2 is 25mmhg, the hb percent saturation is 50 percent.
and po2 is only the dissolved form of o2 in the blood. right?
yeah u are absolutely right ..
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Old 09-05-2011
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@salz: I am confused... Why are you asking questions that you already know the answer to?
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Old 09-05-2011
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Originally Posted by salz View Post
ok so my question to u is, what does it do to p50, and what is p50? and what is the diff between p50 and po2?
never mind, ill jus answer myself. lol
p50 is like 50 percent saturation of O2 with the Hb. means that when po2 is 25mmhg, the hb percent saturation is 50 percent.
and po2 is only the dissolved form of o2 in the blood. right?
btw, the magic number for p50 is 26 (or 26.8 mmHg)
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  #7  
Old 09-06-2011
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@salz: I am confused... Why are you asking questions that you already know the answer to?
i am answering it cuz it helps me remember ... i don't see any rule that i cannot just ask and explain.
do what helps you ! lol
plus the question and answer can give good stimulus to study!
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Old 09-06-2011
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i am answering it cuz it helps me remember ... i don't see any rule that i cannot just ask and explain.
do what helps you ! lol
plus the question and answer can give good stimulus to study!
just wondering it made me rethink the whole mechanism, so it was definitely good you asked. but maybe you should have waited a little bit to give the answer...
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Old 09-06-2011
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I am confused with terminology...
2,3-BPG.
Comes from HMP shunt... Shifts O2 dissociation curve to the right.
Is 2,3-BPG and 2,3-DPG is the same thing?
While watching Kaplan videos i keep my notes in front of me where it says 2,3-BPG, but the lecturer on the video would insist on DPG...
So where is truth?
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Old 09-06-2011
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Quote:
Originally Posted by DocSikorski View Post
I am confused with terminology...
2,3-BPG.
Comes from HMP shunt... Shifts O2 dissociation curve to the right.
Is 2,3-BPG and 2,3-DPG is the same thing?
While watching Kaplan videos i keep my notes in front of me where it says 2,3-BPG, but the lecturer on the video would insist on DPG...
So where is truth?

Yes, it is the same thing. It is 2,3-Biphosphoglycerate and 2,3-Diphosphoglycerate, which is essentially the same.
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  #11  
Old 09-06-2011
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Originally Posted by val7 View Post
just wondering it made me rethink the whole mechanism, so it was definitely good you asked. but maybe you should have waited a little bit to give the answer...
hahaha its a good brain exercise. ...
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  #12  
Old 09-06-2011
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Quote:
Originally Posted by DocSikorski View Post
I am confused with terminology...
2,3-BPG.
Comes from HMP shunt... Shifts O2 dissociation curve to the right.
Is 2,3-BPG and 2,3-DPG is the same thing?
While watching Kaplan videos i keep my notes in front of me where it says 2,3-BPG, but the lecturer on the video would insist on DPG...
So where is truth?
yes they are both the same and inc in them cause right shift and dec in them cause left shifft of o2-hb dissociation curve!
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