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Old 09-06-2011
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Question myxedema in hypothyroidism or hyperthyroidism?

guys can u please explain whether myxedema is present in hypothyroid or hyperthyroidism?
if both of them are in the options what is the best option?
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Old 09-06-2011
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MYXEEMA IS PRESENT IN HYPO FUNCTIONING OF THYROID GLAND .
myxedema is an adult disorder .
in which there is edematous growth, bagginess under the eyes, atherosclerosis and arterosclrosis.
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Old 09-06-2011
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Quote:
Originally Posted by samba View Post
MYXEEMA IS PRESENT IN HYPO FUNCTIONING OF THYROID GLAND .
myxedema is an adult disorder .
in which there is edematous growth, bagginess under the eyes, atherosclerosis and arterosclrosis.

How do you explain myxedema as a component of Grave Dx ?

2 Distinct characteristic of grave disease are Ophthalmopathy and Mixedema...

For me is a HyperThyroid Thing... =)
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Old 09-06-2011
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well goljan says that its in hyperthyroidism but when i read under hypothyroidism, myxedema was mentioned there as well... and also how u differnetiate graves from toxic nodular goiter is presence of both exophthalmos and myxedema which are present in graves but not in toxic nodular goiter..
so i was doing questions today and kaplan qbank says that myxedema is present in hypothyroid!
what the ..? lol
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Old 09-06-2011
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Ok, that's a different things...

Myxedema "preorbital and facial" are characteristic of Hypothyrodism, but Pretibial Myxedema are found in Graves.... =)

Hope it helps clarify your concepts...
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Old 01-21-2012
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I've read somewhere (don't remember the source) that the mechanism of GAG deposition is via stimulation of TSH receptors on fibroblasts. increase GAG deposition is called Myxedema ( mucus like)
In hypothyroidism, there is increase in TSH --- GAG deposit- causes periorbital puffiness and hoarseness of voice.
In Graves GAG deposit causes ---- Exophthalmos and pretibial myxedema. Graves has IgG that stimulates TSH receptors therefore theses are only present in graves and not dt other hyperthyroidism causes.

Why GAG deposits in these sites is unknown

Hope this helps, this is my first post!
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Old 04-16-2014
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Just want to add a slight addition to what Meed86 said, based on what I've read in Mosby's Physiology.

MYXEDEMA

Hypothyroidism = because of lack of thyroid hormones

Normally, thyroid hormones (T3 & T4) inhibit the synthesis and increase the degradation of mucopolysaccharides (glycosaminoglycans = GAGs) and fibronectin in the extracellular connective tissue.

In hypothyroidism, without sufficient thyroid hormones, the accumulation of subcutaneous GAGs and other matrix molecules will result in cool and dry skin and a puffy face (= facial/periorbital myxedema).

Hyperthyroidism = because of anti-TSH receptor antibodies

The anti-TSH receptor antibodies recognize a similar epitope on skin fibroblasts (= pretibial myxedema).

EXOPHTHALMOS/PROPTOSIS

Hyperthyroidism = because of anti-TSH receptor antibodies

The anti-TSH receptor antibodies recognize a similar epitope on orbital fibroblasts.

Last edited by phlebgirl; 04-16-2014 at 06:27 AM.
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