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  #1  
Old 09-10-2011
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Question Cancer and Gene

A 32-year-old patient with a history of medullary thyroid carcinoma has come to your office. Mutation at which of the following genes may indicate a need for further evaluation for presence of hyperparathyroidism in this patient?

A) p21Ras
B) BRCA-1
C) BAX
D) ret
E) Bcl-2
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Old 09-10-2011
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Default D) - ret

RET oncogene is related to Multiple Endocrine Neoplasia Types IIa and IIb.
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Old 09-10-2011
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Quote:
Originally Posted by m82_ghasemi View Post
A 32-year-old patient with a history of medullary thyroid carcinoma has come to your office. Mutation at which of the following genes may indicate a need for further evaluation for presence of hyperparathyroidism in this patient?

A) p21Ras
B) BRCA-1
C) BAX
D) ret
E) Bcl-2
D) ret gene.
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  #4  
Old 09-10-2011
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definitely D. ret
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Old 09-11-2011
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Default

D) ret gene
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  #6  
Old 09-11-2011
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Default

Quote:
Originally Posted by m82_ghasemi View Post
A 32-year-old patient with a history of medullary thyroid carcinoma has come to your office. Mutation at which of the following genes may indicate a need for further evaluation for presence of hyperparathyroidism in this patient?

A) p21Ras
B) BRCA-1
C) BAX
D) ret
E) Bcl-2


d) ret gene
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  #7  
Old 09-11-2011
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D.ret gene
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Old 09-12-2011
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Thumbs Up Cancer and proto-oncogenes

Quote:
Originally Posted by m82_ghasemi View Post
A 32-year-old patient with a history of medullary thyroid carcinoma has come to your office. Mutation at which of the following genes may indicate a need for further evaluation for presence of hyperparathyroidism in this patient?

A) p21Ras
B) BRCA-1
C) BAX
D) ret
E) Bcl-2

Well done guys!
The correct answer is D) ret.

The RET proto-oncogene encodes a receptor tyrosine kinase for members of the glial cell line-derived neurotrophic factor family of extracellular signalling molecules. RET loss of function mutations are associated with the development of Hirschsprung's disease, while gain of function mutations are associated with the development of various types of human cancer, including medullary thyroid carcinoma, multiple endocrine neoplasias type 2A and 2B, phaeochromocytoma and parathyroid hyperplasia.
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  #9  
Old 09-13-2011
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Default Hello

Ret gene is resposible
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