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  #1  
Old 09-11-2011
dr.morphine's Avatar
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Default 5' utr!

A 12 yr old boy presents to the neurologist with rigidity.bradykinesia,intention tremor,uncoordinated gait.small deposits are seen in the cornea.genetic testing shows a mutation in the short 5'UTR region of the gene associated with this disease.another gene x was discovered on the opposite noncoding strand of the disease gene.the translation start codon of the disease gene is located near the end of the 1st exon on gene x.the polymorphism described is most likely to be complimentary to which of the following?

a. 3'UTR of gene x
b. 5' UTR of gene x
c. first exon of gene x
d. first intron of gene x
e. last exon of gene x
f. last intron of gene x

pheeeewwww that was along question!! please tell me the answer with EXPLANATIOn... im lost here
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  #2  
Old 09-11-2011
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Quote:
Originally Posted by drmeena View Post
A 12 yr old boy presents to the neurologist with rigidity.bradykinesia,intention tremor,uncoordinated gait.small deposits are seen in the cornea.genetic testing shows a mutation in the short 5'UTR region of the gene associated with this disease.another gene x was discovered on the opposite noncoding strand of the disease gene.the translation start codon of the disease gene is located near the end of the 1st exon on gene x.the polymorphism described is most likely to be complimentary to which of the following?

a. 3'UTR of gene x
b. 5' UTR of gene x
c. first exon of gene x
d. first intron of gene x
e. last exon of gene x
f. last intron of gene x

pheeeewwww that was along question!! please tell me the answer with EXPLANATIOn... im lost here
5' end of gene x will have first exon and it has disease gene. Now 5' end of coding strand which also mutated will have bonds with 3' end of gene x.
So answer may be A- 3'UTR of gene x.
Still confusing, what's the meaning of giving first exon of gene x.!!!
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Old 09-11-2011
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I think it's D, first intron.
The 5'UTR is upstream from the point translation starts (this in the diseased gene).
Now gene x is in the opposite strand (it is read in the opposite direction), and we know the translation start in the diseased gene matches the end of the first exon in gene x.
Thus the mutation will be downstream from exon 1 in gene x. Downstream from exon 1 is likely intron 1.
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Old 09-11-2011
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Quote:
Originally Posted by patient doctor View Post
I think it's D, first intron.
The 5'UTR is upstream from the point translation starts (this in the diseased gene).
Now gene x is in the opposite strand (it is read in the opposite direction), and we know the translation start in the diseased gene matches the end of the first exon in gene x.
Thus the mutation will be downstream from exon 1 in gene x. Downstream from exon 1 is likely intron 1.
yeah u are right i was thinking D also ....
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