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Old 09-13-2011
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GIT The Mechanism of action of Gastrin?

A blood gastrin level of more than 1,000 pg/mL is practically diagnostic of AA Blood gastrin level of more than 1,000 pg/mL is practically diagnostic of Zollinger-Ellison syndrome. Patients with Zollinger-Ellison syndrome have severe acid over-production due to this elevation in gastrin. What is the mechanism of action of gastrin?
  • A. Gastrin acts on the H2 receptor on parietal cells
  • B. Gastrin acts on the gastrin receptor on parietal cells and stimulates release of histamine by ECL cells
  • C. Gastrin acts on the M3 receptor and stimulates ECL cells to secrete prostaglandins
  • D. Gastrin acts on the gastrin receptor on parietal cells only
  • E. Gastrin acts on the gastrin receptor, leading to PGE2 and histamine release by ECL cells
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B. Gastrin acts on the gastrin receptor on parietal cells and stimulates release of histamine by ECL cells
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I think b
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I think - B
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B. Gastrin acts on the gastrin receptor on parietal cells and stimulates release of histamine by ECL cells
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B.gastrin acts on the gastrin receptor
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B. Gastrin acts on the gastrin receptor on parietal cells and stimulates release of histamine by ECL cells
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Old 09-14-2011
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B. Gastrin acts on the gastrin receptor on parietal cells and stimulates release of histamine by ECL cells
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B. Gastrin acts on the gastrin receptor on parietal cells and stimulates release of histamine by ECL cells
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gastrin acts on gastrin receptors on parietal cells and stimulates release of histamine by ECL cells
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The correct answer is B.
Gastrin stimulates secretion of H+ by parietal cells using a bipartite mechanism. Gastrin acts directly on the parietal cells of the stomach, leading to stimulation of H+ secretion by the H+-K+ ATPase. Gastrin also activates the same gastrin receptor on ECL cells. This causes the ECL cells to secrete histamine, which further stimulates H+ secretion by the parietal cell
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B. Gastrin acts on the gastrin receptor on parietal cells and stimulates release of histamine by ECL cells
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