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Old 01-26-2015
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Default Hepatitis B and Joint Pain

Hi everyone,

I recently encountered a question describing a man with hepatitis B and he had joint pain. They asked what immunologic damage was done to the joints. The options from what I recall are as follows...
a)Cytotoxic
b)Type II Hypersensativity
c)Complement
d)Eosinophillic

Can someone help me with this?

Also why in normal viral prodrome symptoms do we get myalgia or joint pains in general? i know the other symptoms such as fever chills are due to inflammatory cytokines... but what about joint pains? Any explaination on this basic principle would be greatly appreciated!
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Old 01-26-2015
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Quote:
Originally Posted by xxpmoney36xx View Post
Hi everyone,

I recently encountered a question describing a man with hepatitis B and he had joint pain. They asked what immunologic damage was done to the joints. The options from what I recall are as follows...
a)Cytotoxic
b)Type II Hypersensativity
c)Complement
d)Eosinophillic

Can someone help me with this?

Also why in normal viral prodrome symptoms do we get myalgia or joint pains in general? i know the other symptoms such as fever chills are due to inflammatory cytokines... but what about joint pains? Any explaination on this basic principle would be greatly appreciated!

i think it must be type III hypersensitivity and/or cryoglobunemia leading to complement system activation that accumulates and deposits in joints... the same as it occurs in glomerulonephritis MPGN and in MGN ,
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Old 01-27-2015
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Quote:
Originally Posted by xxpmoney36xx View Post
Hi everyone,

I recently encountered a question describing a man with hepatitis B and he had joint pain. They asked what immunologic damage was done to the joints. The options from what I recall are as follows...
a)Cytotoxic
b)Type II Hypersensativity
c)Complement
d)Eosinophillic

Can someone help me with this?

Also why in normal viral prodrome symptoms do we get myalgia or joint pains in general? i know the other symptoms such as fever chills are due to inflammatory cytokines... but what about joint pains? Any explaination on this basic principle would be greatly appreciated!
the transient appearance of circulating complement-fixing immune complexes in patients with the arthritis of acute hepatitis is associated with activation of both classical and alternate complement pathways and suggests that they play an important role in the pathogenesis of these serum sickness-like extrahepatic symptoms.
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