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Old 09-16-2011
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DNA Mutation in 5'UTR

the mutation for wilson disease is located in the short 5'UTR of ATP7B gene. another associated gene (X) was discovered on the opposite non coding strandof the ATP7B gene. the translation start codon is located nearthe end of the first exon of gene X. the mutation of ATP7B gene most likely will be complementary to which of the following?

A) 3'UTR of gene X
B) 5'UTR of gene X
C) first exon of gene X
D) first intron of gene X
E) last intron of gene X
F) last exon of gene X

what is the correct answer? can anyone please explain the answer and the question? thanks
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Old 09-16-2011
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3" utr of gene x ??
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Old 09-16-2011
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Since the translation start codon is located near the end of the first exon of gene( from where tranlation starts i.e 3' region),therefore the mutation of ATP7B gene most likely will be complementary to C) first exon of gene X ??

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D) first intron of gene X
its from Kaplan qbank.
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Old 09-16-2011
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the correct answer is d) the first exon on gene X and its a kaplan qbank question.
could anyone please explain it?
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Old 09-17-2011
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Best explaination is given in qbank with figure. . . Its tough one
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Old 08-16-2012
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Default Didn't understood this point.

Quote:
Originally Posted by dinosaur108 View Post
Best explaination is given in qbank with figure. . . Its tough one
According to explaination.
Mutation in the 5'UTR of ATP7B is involved. Since gene X is located on the opposite strand of ATP7B, its sequence will run in the opposite direction. The 5'UTR should be located immediately upstream of the translation start codon of ATP7B or immediately downsteam of the first exon of gene X, which should correspond to the first intron of gene X.

Understood the whole explanation except this bolded line. May be its too silly. but can anyone clarify me about this. Thanks
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Old 08-17-2012
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Default kaplan is wrong but uworld is correct......regarding this ques.

hello guys,
when i was solving uworld i got similar ques there too,and i answered it correctly,frankly my subscription got expired and i couldnt tell you more on this ques......but one guy wrote the correct answer .....ITS DEFINATELY (C.5'utr of atp7b gene has mutation which would definately correspond to the first exon of gene x.................try to draw diagram and u wud come to know the ans. automaticallly................
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Old 08-17-2012
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Default Ya

Quote:
Originally Posted by eshaan View Post
hello guys,
when i was solving uworld i got similar ques there too,and i answered it correctly,frankly my subscription got expired and i couldnt tell you more on this ques......but one guy wrote the correct answer .....ITS DEFINATELY (C.5'utr of atp7b gene has mutation which would definately correspond to the first exon of gene x.................try to draw diagram and u wud come to know the ans. automaticallly................
Yes C makes sense. Thanks
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Old 08-17-2012
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Quote:
Originally Posted by koolkiller88 View Post
Yes C makes sense. Thanks
YEAH ...........ACTUALLY I SOLVED SIMILAR QUES IN U WORLD THATS WHY I KNOW THE CONCEPT....................KAPLAN QBANK HAS GOT IT WRONG
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