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  #1  
Old 09-19-2011
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Question Excercise study and muscle sample!

26-year-old man participates in an exercise study. He is appropriately classified as sedentary, since his VO2max (maximum oxygen consumption) measured during conventional cycle ergometer exercise is 35 mL/kg/min. The exercise study utilizes a knee-extensor ergometer that limits exercise to the quadriceps muscles. The subject is given a 5-minute unloaded warm-up, which is followed by a graded maximal exercise test and then by 30 minutes of knee-extensor exercise at 50% of the maximum work load. Sixty minutes after termination of the exercise routine, a biopsy is taken from the exercising muscle. Which of the following would most likely be increased in the muscle sample?

A. Basic fibroblast growth factor mRNA
B. Intracellular pO2
C. Mitochondrial volume density
D. Myoglobin oxygen saturation
E. Vascular endothelial growth factor mRNA
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Old 09-19-2011
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ans is A. . .
Its kaplan qbank question
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Old 09-23-2011
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Nope the answer is E
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Old 09-23-2011
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to vasodilate and supply more O2 to the muscles? explain please
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Old 09-23-2011
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Indeed, answer is E.
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Old 09-23-2011
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Ricco or Ruiz,


Where do I go to read materials related to this topic? Thanks
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Old 09-23-2011
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Quote:
Originally Posted by usluipek View Post
Ricco or Ruiz,


Where do I go to read materials related to this topic? Thanks
I think i read it from uw or kaplan qbank. I usually read from FA and complement it with qbank. It max out your comprehension. If i feel any topic is weak i watch the videos relate it to.


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Old 09-23-2011
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Quote:
Originally Posted by dinosaur108 View Post
ans is A. . .
Its kaplan qbank question
Yeah, it reminds me of Kaplan qbank too, but its E) i believe
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Old 09-23-2011
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Oppsss..mistake in hurry
Ya its VEGF. . . .which increases after 1 hr of exercise. . . .also increase in capillary density..
FGF and mitochondrial density take time to to increase
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Old 09-24-2011
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Vascular endothelial growth factor (VEGF) is a heparin-binding glycoprotein that increases endothelial cell proliferation in vitro and capillary growth (i.e., angiogenesis) in vivo. Unlike most other growth factors, VEGF has unique target-cell specificity for vascular endothelial cells, i.e., it does not directly stimulate growth of other types of cells. VEGF mRNA expression is increased in human skeletal muscle within an hour after intensive exercise. This increase in VEGF mRNA expression is followed by increased VEGF protein levels, which can initiate angiogenesis in the muscles. Growth of new blood vessels decreases diffusion distances between capillaries and muscle fibers, thereby improving oxygen transport to the tissues.
Basic fibroblast growth factor (bFGF) (choice A) is a heparin-binding growth factor capable of stimulating angiogenesis. However, bFGF mRNA expression is not increased following an exercise routine such as that described in the vignette.
Exercise decreases myoglobin oxygen saturation (choice D) as well as intracellular pO2(choice B).
Endurance exercise training can stimulate growth of mitochondria in human skeletal muscle and thereby increase mitochondrial volume density (choice C) (i.e., volume of mitochondria per unit volume of muscle); however, growth of new mitochondria will not occur within an hour after exercise.
Vascular endothelial growth factor (VEGF) causes angiogenesis by targeting vascular endothelial cells. Intense exercise leads to increased production of VEGF.
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