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Old 09-20-2011
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Default diagnose

45 yr old male with chr HTN being treated with a novel drug. P/E Dry mucous membrane and orthostasis
Lab values
Na- 129
K - 5.8
CL- 101
HCO3 - 18
BUN- 20
Creat- 0.9
what is the mechanism of the drug

a Antagonist to aldosterone
b Inhibits secretion of renin
c Inhibits Na- Cl transporter in early distal tubule
d Osmotic diureticat proximal tubule
e Inhibits Na- K -Cl cotransporter in thick ascending loop of henle
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  #2  
Old 09-20-2011
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Default A

Quote:
Originally Posted by ricko335 View Post
45 yr old male with chr HTN being treated with a novel drug. P/E Dry mucous membrane and orthostasis
Lab values
Na- 129
K - 5.8
CL- 101
HCO3 - 18
BUN- 20
Creat- 0.9
what is the mechanism of the drug

a Antagonist to aldosterone
b Inhibits secretion of renin
c Inhibits Na- Cl transporter in early distal tubule
d Osmotic diureticat proximal tubule
e Inhibits Na- K -Cl cotransporter in thick ascending loop of henle
A, antagonist to aldosterone
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  #3  
Old 09-20-2011
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a Antagonist to aldosterone

only Potassium diuretics causes hyperkalemia.
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Old 09-20-2011
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d Osmotic diureticat proximal tubule
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  #5  
Old 09-20-2011
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D is the answer
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Old 09-20-2011
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HyperK-emia excludes C (thiazides) and E (loop); osmotic diuretics is not used for chronic HTN
So, between A & B
My guess is A.
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Old 09-20-2011
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A. it must be aldosterone antagonist like spirinolactone which is potassium sparing, hence the hyperkalemia.
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Old 09-20-2011
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Default B.

Quote:
Originally Posted by ricko335 View Post
45 yr old male with chr HTN being treated with a novel drug. P/E Dry mucous membrane and orthostasis
Lab values
Na- 129
K - 5.8
CL- 101
HCO3 - 18
BUN- 20
Creat- 0.9
what is the mechanism of the drug

a Antagonist to aldosterone
b Inhibits secretion of renin
c Inhibits Na- Cl transporter in early distal tubule
d Osmotic diureticat proximal tubule
e Inhibits Na- K -Cl cotransporter in thick ascending loop of henle
I think so it should be a b-blocker for ch.HTN, so B-Inhibits secretion of renin
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Old 09-21-2011
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Default

It is antagonism to aldosterone which is characteristic of a K sparing diuretic like spironolactone


Taken from kaplan q bank
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