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Old 09-21-2011
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Default Carbonic anhydrase Inhibitors reduce ammonium excretion.

Kaplan said ammonium ion is substituted with hydrogen ions at the Na+/H+ antiporter of PCT. So if the CA enzyme is inhibited, there will be no formation of intracellular H+. This means ammonium will not be secreted/excreted as H+ is not there to be substituted with.

Now, i don't see this process anywhere in FA, Katzung pharm, or even Kaplan LN.

can anyone help with the explaination? provide more info perhaps?
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