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Old 02-12-2015
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Default haloperidol and dopamine d2 receptor

In haloperidol
Dopamine d2 receptor is G inhibitory
so how blocking it will inc cAMP
i guess its inhibitory so we should stimulate it to inhibit dopamine
what im missing
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mehdihemmati (02-13-2015)



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Old 02-13-2015
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Quote:
Originally Posted by Hamada View Post
In haloperidol
Dopamine d2 receptor is G inhibitory
so how blocking it will inc cAMP
i guess its inhibitory so we should stimulate it to inhibit dopamine
what im missing
And that's the unwanted effect of haloperidol through indirect pathway. That's why Atypical antipsychotics have been created. (This is what I know maybe the truth is sth else).
Just like Beta blockers. sometimes you don't need Beta2 inhibition so you use b1 blockers (eg, in patients whith thromboangitis obliterans or prinzmetal angina) b2 dilates vessels so inhibition will help them contract worsening the spastic condition.

Last edited by mehdihemmati; 02-14-2015 at 08:49 AM.
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The above post was thanked by:
swwal (02-14-2015)



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