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Old 09-24-2011
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Default wound healing

A 39-year-old alcoholic female falls down and remains on the floor for 2 days. She is brought to the emergency room, where she is noted to have a laceration. After giving the appropriate antibiotics and tetanus shot, it is decided to let the laceration heal via secondary intention. Which cell initiates granulation of this wound?
A. Myofibroblasts
B. Neutrophils
C. Basophil
D. Macrophages
E. Fibroblasts
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Old 09-24-2011
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E.fibroblast
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Old 09-24-2011
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A. myofibroblast.
they would provide the contraction of the wound surface
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Old 09-24-2011
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Quote:
Originally Posted by ricko335 View Post
A 39-year-old alcoholic female falls down and remains on the floor for 2 days. She is brought to the emergency room, where she is noted to have a laceration. After giving the appropriate antibiotics and tetanus shot, it is decided to let the laceration heal via secondary intention. Which cell initiates granulation of this wound?
A. Myofibroblasts
B. Neutrophils
C. Basophil
D. Macrophages
E. Fibroblasts
Yes Myofibroblast
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Old 09-24-2011
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Secondary intension is always by myofibroblst. . .
Primary intension is by surgical sutures. . .
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Old 09-24-2011
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This should be E. Fibroblasts which helps in granulation.

It is NOT Myofibroblast as it helps in wound contracture. Remember granulation formation occurs before contracture and the question is clearly asking Which cell initiates granulation of this wound?

Correct me if I am wrong.
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Old 09-24-2011
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so its fibroblasts?
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Old 09-25-2011
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The correct answer is D.
Macrophages remove cell debris and secrete growth factors that stimulate angiogenesis and the ingrowth of fibroblasts and myofibroblasts leading to formation of granulation tissue, which is highly vascular and fibrotic. Neutrophils and basophils are not involved in the initiation of granulation
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