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Old 09-27-2011
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Default soft tissue tumour

A 5-year-old child presents with a malignant soft tissue tumor in his posterior neck. Laboratory work shows that he has a positive myo D1 protein marker. What tissue is the likely origin of his tumor?
  • A. Cardiac muscle
  • B. Smooth muscle
  • C. Adipocytes
  • D. Skeletal muscle
  • E. White blood cells
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  #2  
Old 09-27-2011
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B .Smooth muscle-- Just a guess .No idea what is D1 marker is!!
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Old 09-27-2011
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Kiddo, 5 year, RhabdoMyosarcoma.

Transcripts for the muscle regulatory gene MyoD1 are expressed during normal skeletal muscle myogenesis and in rhabdomyosarcomas but not in other tissues or in soft-tissue sarcomas..

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1877713/
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D-Skeletal muscle.
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Old 09-27-2011
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Post MyoD1: Rhabdomyosarcoma Marker

D is correct.

MyoD1
: Rhabdomyosarcoma Marker

Rhabdomyosarcomas are myoblast-derived soft tissue sarcomas that express some muscle-specific genes.
MyoD1 is one of several regulatory genes that controls myogenic differentiation. The MyoD1 gene protein is not detected in normal adult tissue but is highly expressed in rhabdoyosarcomas.
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Quote:
Originally Posted by m82_ghasemi View Post
D is correct.

MyoD1: Rhabdomyosarcoma Marker

Rhabdomyosarcomas are myoblast-derived soft tissue sarcomas that express some muscle-specific genes.
MyoD1 is one of several regulatory genes that controls myogenic differentiation. The MyoD1 gene protein is not detected in normal adult tissue but is highly expressed in rhabdoyosarcomas.
its a better explanation
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D. Skeletal muscle
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