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Old 09-27-2011
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Arrow NBME 6 Block 1 Discussion

hey guys can anyone tell the answer for the 3rd question in block 1??

the bar graph shows the results of an experiment in which levodopa was administered orally alone and in the presence of drug X..


the question starts that way...
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Old 09-27-2011
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Simply carbidopa is a peripheral decarboxylase inhibitor and is given with levodopa(l-dopa) in order to increase bioavailability of l-dopa in brain. (because l-dopa given alone can be degraded in peripheral tissue exactly by dopa decarboxylas) when l-dopa riches the brain then its converted to dopamine
C arbidopa also prevent peripheral side effects like arrhythmias
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Old 09-30-2011
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but levodopa+drug X is increasing levodopas effect when given alone in both brain n periphery...so it must b a MAO B inhibitor like selegiline ryt??if it wer carbidopa why would the peripheral level increase in its presence??i found everyone saying the answer is carbidopa...i feel its selegiline?
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Old 08-08-2012
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Quote:
Originally Posted by sonu.agarwall View Post
but levodopa+drug X is increasing levodopas effect when given alone in both brain n periphery...so it must b a MAO B inhibitor like selegiline ryt??if it wer carbidopa why would the peripheral level increase in its presence??i found everyone saying the answer is carbidopa...i feel its selegiline?

carbidopa doesn't cross BBB !
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Old 08-08-2012
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Levels of levodopa is measured not dopamine.

With carbi,
levels of levo-D will increase in both CNS n peripheries but Dopamine levels will increase only in CNS not in periphery
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Old 08-12-2012
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Question block 3 15th q

guys..anyone can tell me the answer for block 3 15th question....i really think the key gave the wrong answer...please explain it..

thanq
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