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  #1  
Old 09-30-2011
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Question Tough Question !

A 66 year old man with a recently discovered lung mass develops dizziness, dysartria, and limb ataxia worsening over the past 2 weeks. He denies other medical conditions and takes no medication. He has smoked 1 pack of cigarettes for the past and denies alcohol and illicit drug use. He is addmited to the hopsital but develops worsening neurological symptoms. Despite appropriate therapy, he dies 2 weeks later. Autopsy shows extensive cerebellar Purkinje cell degeneration. Which of the following best describes the etiology of this patients neurologic condition.

A)Infectious
B)Metastatic
C)Vascular
D)Autoimmune
E)Toxic
F)Endocrine
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Old 09-30-2011
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vascular as punkinje cells and hippocampus most proned to vascular insult....
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Old 09-30-2011
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answer is d) autoimmune. this is from uworld q.id 595 ...paraneoplastic cerebellar degeneration
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Old 09-30-2011
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A 66 year old man with a recently discovered lung mass develops dizziness, dysartria, and limb ataxia worsening over the past 2 weeks. He denies other medical conditions and takes no medication. He has smoked 1 pack of cigarettes for the past and denies alcohol and illicit drug use. He is addmited to the hopsital but develops worsening neurological symptoms. Despite appropriate therapy, he dies 2 weeks later. Autopsy shows extensive cerebellar Purkinje cell degeneration. Which of the following best describes the etiology of this patients neurologic condition.

A)Infectious
B)Metastatic
C)Vascular
D)Autoimmune
E)Toxic
F)Endocrine
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  #5  
Old 09-30-2011
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Exactly, that's a UW question, and the answer is Auto-Immune.
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Old 10-01-2011
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Quote:
Originally Posted by mayursn39 View Post
A 66 year old man with a recently discovered lung mass develops dizziness, dysartria, and limb ataxia worsening over the past 2 weeks. He denies other medical conditions and takes no medication. He has smoked 1 pack of cigarettes for the past and denies alcohol and illicit drug use. He is addmited to the hopsital but develops worsening neurological symptoms. Despite appropriate therapy, he dies 2 weeks later. Autopsy shows extensive cerebellar Purkinje cell degeneration. Which of the following best describes the etiology of this patients neurologic condition.

A)Infectious
B)Metastatic
C)Vascular
D)Autoimmune
E)Toxic
F)Endocrine
Explanation please??
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Old 10-01-2011
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Paraneoplastic Syndromes occur due to tumor cells producing substances that frequently induce an autoimmune reaction and can cause damage and degeneration of healthy organs and tissues.Neurologic PNS such as paraneoplastic cerebellar degeneration is considered to be AUTOIMMUNE.

PNS cerebellar degeneration is a type of PNS most commonly associated with cancers of the lung,breast,ovary,uterus,and lymphoma.

HOpe that helped! & Thanks for reminding me of this answer as well!=)
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