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Old 10-01-2011
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Kidney Kidney's most susceptible area for ischemia?

Which region of the kidney is most susceptible to ischemia? can anyone tell me plz
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Old 10-01-2011
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Straight portion of PCT and ascending part of loop of henle because
1) These areas require ATP
2) They have low blood flow as they lie on cortico medullary junction
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the options were: cortex - calyxes- papillae
so we go for cortex
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The question might be asking area where the oxygen saturation is the least..
If that is the question then the answer is Renal papillae.
correct me if i am wrong.
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okay let me tell u what they asked exactly
they said a pregnant woman came with DIC which area of the kidney is most susceptible to ischemia and they gave the answers above
so what you think now?
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people with DIC and vasospams have bilateral cortical necrosis.. GIVEN in FA renal chapter
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Old 04-23-2012
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Its Stated in Kaplan Lecture Notes first page of Nephrology (physio) that since MEDULLA has the lowest 02 consumption therefore it is most susceptible to ischemic danage.
P.S Correct me if im wrong.

Thanks.
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Old 04-23-2012
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Wouldn't it be the cortex? Since only 10% of nephrons are actually long enough to make it down to the medulla, therefore most nephrons don't even make it out of the cortex...
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Old 04-23-2012
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Quote:
Originally Posted by yasirmsd View Post
Its Stated in Kaplan Lecture Notes first page of Nephrology (physio) that since MEDULLA has the lowest 02 consumption therefore it is most susceptible to ischemic danage.
P.S Correct me if im wrong.

Thanks.
absoloutely wrong... think of what u just wrote
if u dont consume lots of oxygen... u wont die if it suddenly goes away,,, what dies is what always uses oxygen for energy, which is what the guys already said... THE CORTEX
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Old 04-23-2012
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Most susceptible to ischemia parts are:

Proximal tubule and thick ascending limb of Henle loop
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Old 04-23-2012
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Did the original poster post the answer??
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Old 05-11-2014
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Default kidney ischemia - HARRISON

HARRISON 18th edition

Healthy kidneys receive 20% of the cardiac output and account for 10% of resting oxygen consumption, despite constituting only 0.5% of the human body mass.
The kidneys are also the site of one of the most hypoxic regions in the body, the renal medulla. The outer medulla is particularly vulnerable to ischemic damage because of the architecture of the blood vessels that supply oxygen and nutrients to the tubules. Enhanced leukocyte-endothelial interactions in the small vessels lead to inflammation and reduced local blood flow to the metabolically very active S3 segment of the proximal tubule, which depends on oxidative metabolism for survival.
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Old 05-13-2014
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Quote:
Originally Posted by dr.muhamad View Post
the options were: cortex - calyxes- papillae
so we go for cortex
Cortex(PCT) most susceptible followed by Medulla (TAL)
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