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Old 10-02-2011
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Drug Nitroglycerine Mechanism of Action!

A patient with myocardial infarction is treated with nitroglycerin to dilate his coronary arteries. Which of the following best describes the action of nitroglycerin?
A. Methylation occurs to produce S-adenosylmethionine
B. GTP hydrolysis accomplishes oxidation of LDL proteins
C. Arginine is converted to a neurotransmitter that activates guanyl cyclase
D. Acetyl CoA and choline are condensed to form a neurotransmitter
E. Tyrosine is converted to serotonin
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A patient with myocardial infarction is treated with nitroglycerin to dilate his coronary arteries. Which of the following best describes the action of nitroglycerin?
A.Methylation occurs to produce S-adenosylmethionine
B.GTP hydrolysis accomplishes oxidation of LDL proteins
C.Arginine is converted to a neurotransmitter that activates guanyl cyclase
D.Acetyl CoA and choline are condensed to form a neurotransmitter
E.Tyrosine is converted to serotonin
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The answer is: C
Nitroglycerin causes release of nitric oxide (NO), which activates guanyl cyclase, produces cyclic GMP, and causes vasodilation. NO is formed from one of the guanidino nitrogens of the arginine side chain by the enzyme nitric oxide synthase. NO has a short half-life, reacting with oxygen to form nitrite, then nitrates that are excreted in urine. Coronary vasodilation caused by nitroglycerin is thus short-lived, making other measures
necessary for long-term relief of coronary occlusion. The neurotransmitter formed by condensation of acetyl CoA and choline is acetylcholine.
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C. Arginine is converted to a neurotransmitter that activates guanyl cyclas
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C. Arginine is converted to a neurotransmitter that activates guanyl cyclase
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Old 10-03-2011
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the correct answer is c
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